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Understanding the Role of Smad4 in Intestinal Homeostasis and Tumorigenesis
(2014-07-31)
Colorectal carcinoma is the third leading cause of cancer related mortality within the United States. Over 90% of these deaths can be attributed to distant metastasis. Therefore, understanding the signaling perturbations ...
Composition, Regulation, and Function of Protein Serine/Threonine Phosphatase•Kinase Signaling Modules
(2014-04-14)
The macromolecular assembly of protein serine/threonine phosphatase•kinase complexes mechanistically enhances the speed and fidelity of cell signaling events. These signaling modules allow for acute regulation of substrates ...