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Control of Wnt Trans-Synaptic Signaling by Secreted Extracellular Regulators
(2020-02-17)
In the nervous system, Wnts act as potent regulators of synaptic connectivity, architecture, neurotransmission strength and activity-dependent plasticity. As the founding Wnt, Drosophila Wingless (Wg) has key roles at the ...
Characterization of novel genes regulating the synaptic vesicle cycle in drosophila
(2010-08-04)
A systematic Drosophila forward genetic screen for photoreceptor synaptic transmission mutants identified no-on-and-no-off transient C (nonC) based on loss of retinal synaptic responses to light stimulation. The cloned ...
The evolutionary ecology of an insect-fungus interaction: <i>Botryosphaeria dothidea</i>, symbiotic with the goldenrod-galling midge <i>Asteromyia carbonifera</i> (Diptera: Cecidomyiidae)
(2010-08-05)
Arguably, the process of adaptive ecological speciation and radiation has been the most important mechanism in contributing to the world’s immense biological diversity. Initial theoretical treatments of adaptive speciation ...
Quantifying phylogenetic incongruence and identifying contributing factors in a yeast model clade
(2014-08-20)
The presence of phylogenetic incongruence, the topological conflict between different gene trees, continues to confound phylogeneticists and makes the determination of the major branches of the tree of life challenging. ...
DNA Damage Signaling Orchestrates SV40 Chromatin Replication
(2013-09-06)
The effects of DNA damage signaling on the DNA replication of the polyomavirus SV40 are examined in this dissertation. Infection of monkey cells with SV40 results in large amounts of cellular DNA damage signaling through ...
Inhibition of GABA Initiates Retina Regeneration in the Zebrafish
(2016-07-27)
Retina damage or disease in humans often leads to reactive gliosis, preventing the formation of new cells and resulting in visual impairment or blindness. Currently, treatments are being developed to stimulate repair or ...
Characterization of the essential pre-mRNA splicing factor PSF: investigation of RNA binding specificity and splicing-related complex formation
(2005-08-11)
PSF (PTB-associated splicing factor) has been implicated in both early and late steps of pre-mRNA splicing as well as multiple nuclear events including transcription regulation, nuclear RNA retention/export, topoisomerase ...
Analysis of ZNF9 function in cap-independent translation and myotonic dystrophy type 2
(2010-08-13)
Myotonic dystrophy type 2 (DM2) is an autosomal dominant human disease caused by the expansion of a tetranucleotide repeat in the first intron of the ZNF9 gene. While multiple studies link nucleotide expansions such as ...
Exploring the importance of mosquito hemocoelic and salivary gland components during host-pathogen interactions
(2012-09-27)
Traversal of the hemocoel, avoiding or surviving interactions with the insect’s innate immune system, invasion of the female mosquito’s salivary glands, and injection into the vertebrate host, are necessary steps for disease ...
Contributions to telomerase anchor-site and template/primer alignment functions by yeast TERT residue E76
(2011-09-02)
This project explores the synthesis of heterogeneous G1-3T yeast telomere sequences by the enzyme telomerase. I demonstrate that a mutant in the essential N-terminal TEN domain of Est2p (telomerase reverse transciptase), ...