Search
Now showing items 1-10 of 125
Functional implications of electrophilic protein adducts
(2016-11-17)
Oxidative stress is a contributing factor in a number of chronic diseases, including cancer, atherosclerosis, and neurodegenerative diseases. Lipid peroxidation that occurs during periods of oxidative stress and decomposition ...
Mechanisms of Cisplatin Resistance in Triple Negative Breast Cancer
(2014-11-26)
Genomic instability and deregulated proliferation are hallmarks of human tumors. Cytotoxic chemotherapeutics, including cisplatin, have been used for over forty years to combat cancers that have deregulated proliferation ...
Mechanisms of neurite outgrowth inhibition by Myelin-associated glycoprotein
(2010-12-22)
Axonal regeneration in the central nervous system is prevented, in part, by inhibitory proteins expressed by myelin, including Myelin-associated glycoprotein (MAG). Although injury to the corticospinal tract can result ...
Structural and Mechanistic Observations of the FosX Class of Fosfomycin Resistance Proteins
(2006-12-01)
The objective of this research was to investigate the structure and catalytic mechanisms of the FosX protein class. These enzymes are epoxide hydrolases that disrupt the first step of bacterial cell wall biosynthesis, ...
Bioretrosynthetic Construction of a Non-Natural Nucleoside Analog Biosynthetic Pathway
(2013-12-03)
Engineered biocatalysts have become increasingly sought after as replacements for individual chemical synthetic steps. However, their implementation in multistep sequences as biosynthetic pathways has proven to be a ...
Identification and regulation of p53 target genes in primary human epidermal keratinocytes
(2006-12-07)
BIOCHEMISTRY
IDENTIFICATION AND REGULATION OF P53 TARGET GENES IN PRIMARY HUMAN EPIDERMAL KERATINOCYTES
KRISTY L. SCHAVOLT
Dissertation under the direction of Professor Jennifer A. Pietenpol
The p53 tumor suppressor ...
Assessing the Components of the eIF3 Complex and Their Phosphorylation Status
(2011-12-09)
BIOCHEMISTRY
ASSESSING THE COMPONENTS OF THE eIF3 COMPLEX AND THEIR PHOSPHORYLATION STATUS
ADAM RICHARD FARLEY
Dissertation under the direction of Professor Andrew J. Link
The eukaryotic initiation factor 3 (eIF3) is ...
ETAA1 promotes genome stability through activation of ATR
(2018-11-21)
The ATR kinase controls cell cycle transitions and the DNA damage response. Budding yeast contain three activators of Mec1ATR; however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication ...
Mechanistic Insights into Fosfomycin Resistance: Examination of the FosX Class of Fosfomycin Resistance Proteins
(2005-12-05)
The objective of this research was to examine the FosX class of metalloenzymes utilized by pathogenic microorganisms for resistance to the antibiotic fosfomycin. Fosfomycin is an extremely stable natural product produced ...
Investigations into Allosteric Mechanisms of G Protein Activation
(2013-12-09)
The G protein coupled receptor (GPCR) family is comprised of ubiquitous, membrane-bound proteins that are highly conserved in structure, yet varied in their cognate ligand. This allows for regulation of diverse physiological ...