Browsing Electronic Theses and Dissertations by Department "Molecular Pathology & Immunology"
Now showing items 1-15 of 15
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(2023-06-22)Department: Molecular Pathology & ImmunologyWomen have higher rates of severe asthma compared to men. Severe asthma is characterized by increased Th2-mediated eosinophils and/or Th17-mediated neutrophils in the airway, leading to increased airway hyperresponsiveness ...
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ATP Citrate Lyase and mitochondrial membrane potential regulate hematopoietic cell fate and function (2023-03-23)Department: Molecular Pathology & ImmunologyIn addition to their role in bioenergetic homeostasis, mitochondria are increasingly appreciated as regulators of hematopoietic cell fate and function. Here, we demonstrate the role of ATP citrate lyase (ACLY) on murine ...
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(2022-02-02)Department: Molecular Pathology & ImmunologyCancer resequencing studies have revealed epigenetic enzymes as common targets for recurrent mutations. The monomethyltransferase MLL3 is among the most recurrently mutated enzymes in ER+ breast cancer. The H3K4me1 marks ...
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(2023-11-17)Department: Molecular Pathology & ImmunologyGenomic and transcriptomic analysis have revolutionized our understanding of many cancers. However, genomic understanding of thyroid cancer has lagged behind other tumors; currently, thyroid cancer management is largely ...
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(2022-11-18)Department: Molecular Pathology & ImmunologyT cells of the immune system are critical for an adaptive immune response to infection. T cells are unique among immune cells in that they require an intermediate cell, termed antigen presenting cell (APC), to process and ...
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(2023-03-24)Department: Molecular Pathology & ImmunologyInflammation of bone, or osteomyelitis, is most commonly caused by infection with the Gram-positive bacterium Staphylococcus aureus. During S. aureus osteomyelitis, the homeostasis-maintaining activities of bone cells are ...
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(2022-03-27)Department: Molecular Pathology & ImmunologyVaccines represent one of the most successful medical interventions in history, and their efficacy is dependent on the induction of a robust and long-lasting immune response, classically through the elicitation of neutralizing ...
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(2022-11-08)Department: Molecular Pathology & ImmunologyThe inflammasome is a multi-protein signaling pathway in immune and epithelial cells important for activation of the innate immune system and protection from pathogens. We previously showed that caspase-1 signaling in ...
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(2022-05-11)Department: Molecular Pathology & ImmunologyMetabolism determines cell function and fate across tissues and disease states. Proliferative cells upregulate anabolic metabolism to support cell growth, division, and other activities. Glucose and glutamine are critical ...
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(2023-06-15)Department: Molecular Pathology & ImmunologyTumor-specific CD8 T cells (TST) found in patients with cancer are unable to halt cancer progression. TST are dysfunctional and cannot produce effector cytokines or kill target cells1. TST dysfunction, also known as ...
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(2021-09-16)Department: Molecular Pathology & ImmunologyMethicillin-resistant Staphylococcus aureus (MRSA) is a major cause of skin and soft tissue infections in health care settings and those with diabetes worldwide. There is an unmet clinical need to develop new immunotherapeutic ...
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(2022-03-02)Department: Molecular Pathology & ImmunologyOne-third of all humans, more than 1.5 billion people living in developing countries, are suffering from helminth infection. A vigorous type 2 immune response, characterized by highly elevated levels of IgE, is the hallmark ...
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(2023-09-22)Department: Molecular Pathology & ImmunologyAtherosclerosis is an immune mediated hyperinflammatory disease driven by the retention and oxidation of low-density lipoprotein (LDL) in the vessel wall. The goal of this work was to determine how oxidized LDL (oxLDL) ...
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Single-cell characterization of antibody responses in coronavirus infection and COVID-19 vaccination (2021-09-08)Department: Molecular Pathology & ImmunologyThe COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has resulted in the illness and death of millions of people worldwide. Although medical countermeasures including monoclonal antibody cocktails and vaccines ...
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(2022-03-02)Department: Molecular Pathology & ImmunologyType 1 Diabetes (T1D) is an autoimmune disease characterized by destruction of the pancreatic beta cells by autoreactive lymphocytes. While autoreactive CD8+ T cells, CD4+ T cells, and B cells collaborate to destroy beta ...