Browsing Electronic Theses and Dissertations by Author "Quaranta, Vito"
Now showing items 1-14 of 14
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Meyer, Christian Thomas; 0000-0002-8719-6522 (2020-03-10)Department: Chemical & Physical BiologyTwo goals motivate treating diseases with drug combinations: reduce off-target toxicity by minimizing dose (synergistic potency), and improve outcomes by escalating effect (synergistic efficacy). Surprisingly, current drug ...
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Irvin, Michael; 0000-0001-9919-6565 (2021-07-16)Department: Interdisciplinary Studies: <Major>Extracting biological knowledge from experimental data continues to be one of the main challenges toward a mechanistic understanding of cellular processes. Mathematical models can provide mechanistic insights into the ...
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Ildefonso, Geena Victoria; 0000-0003-0838-2018 (2022-03-18)Department: Chemical & Physical BiologyA central challenge in biomedical research is to understand how cells process information, respond to perturbations, and make decisions. Cells are constantly processing extracellular stimuli that can lead to multiple ...
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Hayford, Corey Eduardo; 0000-0002-3006-4852 (2021-03-08)Department: Biomedical SciencesTumor heterogeneity and plasticity are key contributors to treatment insensitivity and eventual recurrence in oncogene-addicted cancers. Sources of this variability have been ascribed to genetic, epigenetic, stochastic, ...
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Wandishin, Clayton Michael; 0000-0002-6779-7451 (2022-03-30)Department: OtherSmall cell lung cancer (SCLC) is a highly aggressive disease, characterized by a signature “tumor recurrence” during treatment, wherein after initial favorable response, tumors re-establish themselves and no longer respond ...
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Hansen, Tyler John; 0000-0003-3328-783X (2023-03-24)Department: BiochemistryGene regulatory divergence between species can result from cis-acting local changes to regulatory element DNA sequences or global trans-acting changes to the regulatory environment. Understanding how these mechanisms drive ...
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Senosain Ortega, Maria Fernanda; 0000-0002-3933-7167 (2022-05-16)Department: Cancer BiologyLung adenocarcinoma (LUAD) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. While screening programs have proven to significantly increase the chance of ...
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Pino, James; 0000-0001-9882-6748 (2020-07-13)Department: Chemical & Physical BiologyPredicting how cells respond to drugs is a core concept in systems biology modeling. Current available methods for these signaling analyses can be broadly be classified into two categories: local “bottoms-up” and global ...
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Heiser, Cody Nicholas; 0000-0002-1299-1628 (2023-03-14)Department: Chemical & Physical BiologySystems biology leverages high-dimensional molecular data at single-cell and spatial resolution to elucidate and characterize emergent phenomena in human health and disease. Through data-driven modeling and integration, ...
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Taylor, Brandie Chasity; 0000-0002-4862-4678 (2024-03-26)Department: Cancer BiologyAlthough immune checkpoint inhibition (ICI) has proven successful in treating cancer, patients with triple-negative breast cancer (TNBC) often develop therapy resistance, and the underlying mechanisms remain unclear. MHC-I ...
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Sinnaeve, Justine; 0000-0001-9303-7969 (2020-06-15)Department: Cancer BiologyGlioblastoma is the most common malignant primary brain tumor and is rapidly fatal despite aggressive treatment with chemoradiation and therapy. Single cell approaches to uncovering intra- and inter-tumor heterogeneity ...
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Artis, Erica; 0000-0002-1560-323X (2022-03-29)Department: Cell & Developmental BiologyThe myoepithelial cell compartment of the murine postnatal mammary gland is generated from basal cap cells in the terminal end bud and maintained by self-renewal. Transdifferentiation to the luminal lineage does not normally ...
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Chen, Bob; 0000-0003-1508-1758 (2022-02-11)Department: Chemical & Physical BiologyComplex systems contain several hierarchical levels of abstracted information and function, which attenuate the effectiveness of traditional analytical methods. The application of systems theory and machine learning for ...
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Cleland, Joseph Anthony; 0000-0002-5848-6467 (2021-06-08)Department: Chemical & Physical BiologySignal transduction is the process by which an external signal is transmitted into a cell to induce a cellular response. Cells have evolved robust mechanisms to interpret and respond to these external signals as they modify ...