Browsing Electronic Theses and Dissertations by Department "Neuroscience"
Now showing items 81-100 of 232
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(2020-07-23)Department: NeuroscienceA lack of animal models representing adequately epilepsy syndromes has hindered advancing treatment for patients. Epileptic encephalopathies are a severe subset of epilepsies associated with a high probability of impaired ...
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(2007-07-30)Department: NeuroscienceIn order to form synaptic connections, an individual neuron needs to coordinate the activities of a large number of proteins. The neuron can modulate the activity of these proteins in a variety of ways. For instance, ...
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Gene-Environment Interactions Between Manganese Toxicity and Early-Onset Parkinson's Disease Genes (2015-03-26)Department: NeuroscienceParkinson’s disease (PD) is a neurodegenerative, motor disorder that is characterized by selective dopaminergic cell loss in the substantia nigra pars compacta. About 10-20% of PD cases have genetic causes; nonetheless, ...
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(2013-11-22)Department: NeuroscienceAttention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed childhood neuropsychiatric disorder. More than twenty years of genetic, behavioral, and pharmacological research support the hypothesis that ...
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(2013-03-29)Department: NeuroscienceIn the brain, serotonin (5-hydroxtryptamine, 5-HT) is synthesized in the raphe nucleus. Raphe serotonergic projections modulate neurotransmissions throughout the brain influencing mood and behavior. The serotonin transporter ...
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(2013-04-22)Department: NeuroscienceSKF83959 is a high affinity dopamine D1 receptor agonist that has been reported to preferentially activate D1 receptors coupled to G(alpha)q. This pathway results in phosphatidylinositol hydrolysis, intracellular calcium ...
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(2011-04-07)Department: NeuroscienceCurrent estimates suggest that as many as 9% of Americans meet the DSM-IV criteria for substance use disorders, and the annual economic burden of substance abuse has been assessed at approximately half a trillion dollars. ...
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(2008-04-15)Department: NeuroscienceNeuroscience Dissertation under the direction of Professor Randy D. Blakely This dissertation is focused on the function and regulation of the choline transporter (CHT). I used CHT heterozygous and homozygous mice, and ...
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(2014-10-29)Department: NeuroscienceEpilepsy is a common neurological disease characterized by an enduring predisposition to generate seizures. Although multiple factors contribute to epilepsy, the majority of cases are genetic in origin. Variable expressivity ...
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(2005-07-12)Department: NeuroscienceThis dissertation describes pharmacological studies of the functional consequences of the Cys23Ser single nucleotide polymorphism (SNP) in two different edited versions of the human 5-HT2C receptor as well as evaluation ...
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(2013-09-13)Department: NeuroscienceCoordinated neurotransmission of fast acting neurotransmitters like glutamate (GLU) and neuromodulators such as dopamine (DA) is critical for the proper execution of complex behaviors such as cognition, locomotor control, ...
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(2013-11-25)Department: NeuroscienceEpilepsy is a neurological disorder affecting approximately 3 million Americans. Two-thirds of patients diagnosed with epilepsy have no known cause for their disease, however recent evidence suggests most result from complex ...
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(2009-09-29)Department: NeuroscienceGliomas are the predominant type of primary central nervous system tumors. They are highly invasive and notoriously refractory to current therapies. Patients diagnosed with a malignant glioma face a dismal prognosis that ...
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(2011-12-09)Department: NeuroscienceMild, moderate, and vigorous physical activity are associated with decreased risks of Alzheimer’s disease, Parkinson’s disease, and a decreased infarct from stroke. Physical activity increases neurogenesis in the hippocampus ...
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(2015-08-17)Department: NeuroscienceThe hippocampus is a medial temporal lobe structure involved in learning and memory. Several magnetic resonance imaging methods exist to investigate hippocampal structure and function in vivo. Some of these methods provide ...
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(2020-04-07)Department: NeuroscienceThe dopamine transporter (DAT), a presynaptic membrane protein, regulates the temporal and spatial availability of the neurotransmitter dopamine (DA). The precise regulation of synaptic DA by the DAT fine-tunes the phasic ...
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(2010-02-09)Department: NeuroscienceTranscripts encoding 5HT2C receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5HT2C-VGV, exhibits blunted G-protein coupling ...
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Individual Differences in Rhythm and Grammar Phenotypes and Potential Underlying Genetic Influences (2022-03-27)Department: NeuroscienceThis dissertation studied the associations between musical rhythm and grammar phenotypes and underlying polygenic architecture that might influence these traits. These associations were explored using individual approaches ...
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(2016-10-20)Department: NeuroscienceThe immune system and brain are intricately intertwined in both development and adult function. Unfortunately, this relationship can lead to dysfunction when balance in either system is disturbed. Inflammation does not ...
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(2018-08-30)Department: NeuroscienceInhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice Victoria S. Cavener Dissertation under direction of Professor Sachin Patel Elucidating the underlying molecular mechanisms regulating fear and extinction ...