Browsing Electronic Theses and Dissertations by Department "Neuroscience"
Now showing items 61-80 of 232
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(2023-03-29)Department: NeuroscienceThe endocannabinoid (eCB) system, which consists of the cannabinoid receptor type 1 (CB1R) and its endogenous ligand, 2-arachidonoylglycerol (2-AG), as well as key synthesis and degradation enzymes, can promote bidirectional, ...
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(2012-10-09)Department: NeuroscienceThe epithalamus of the zebrafish contains the dorsal habenulae (Dh), a bilateral pair of nuclei characterized by significant left-right asymmetries in gene expression, anatomy, and connectivity. A screen for mutations that ...
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(2014-11-26)Department: NeuroscienceEpilepsy is a neurological disorder affecting almost one percent of the population, and genetic epilepsy are those caused by a presumed or unknown genetic factor(s). Mutations in GABAA receptors, pentameric chloride ion ...
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(2019-04-02)Department: NeuroscienceEpileptic encephalopathies (EEs) are catastrophic childhood epilepsies with intractable seizures, developmental delays, and cognitive impairment. I determined the functional impact of five de novo GABAA receptor β subunit ...
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(2022-09-16)Department: NeuroscienceEnlarged perivascular spaces (ePVS) are a marker of small vessel disease that have not been well studied. The etiologies and clinical consequences of ePVS are not well studied. The objective of this project was to identify ...
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(2015-12-28)Department: NeuroscienceNEUROSCIENCE Evaluating Multisensory Processing in the Mouse Model: Clinical and Translational Implications Justin Kyle Siemann Dissertation under the direction of Mark T. Wallace Multisensory integration is the synthesis ...
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(2015-07-20)Department: NeuroscienceThe dysfunction of dopamine signaling can contribute to mood disorders and drug abuse. Dopamine neurons do not belong to one homogenous group and differ in their electrophysiological properties and molecular expression ...
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(2013-09-20)Department: NeuroscienceI have studied the neurophysiological bases of saccade execution and evaluation within the oculomotor system of Macaca mulatta and Macaca radiata. To better understand saccade execution, I recorded the electromyogram (EMG) ...
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(2015-08-21)Department: NeuroscienceAlzheimer's disease (AD) is an age-dependent neurodegenerative disorder characterized by a progressive and inexorable loss of cognitive function most likely attributable to the accumulation of amyloid-β (Aβ) peptide in the ...
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(2019-04-11)Department: NeuroscienceThe pulvinar is the largest thalamic subdivision in primates and has deep integration with cortical areas involved with visual perception. Unlike the lateral geniculate nucleus (LGN), which acts as the primary relay in ...
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(2015-08-11)Department: NeuroscienceAdenosine-to-Inosine RNA editing (A-to-I editing) has evolved as an important process for generating transcript diversity in metazoans. Several editing events which effect transcripts encoding proteins important for CNS ...
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Exploring the role of the pulvinar-cortical interactions in vision: a tale of maps, loops and gates (2013-12-03)Department: NeuroscienceThe pulvinar is a dorsal thalamic nucleus strongly associated with the visual system, but of uncertain function. One of the central mysteries of the pulvinar is the direction and quality of the information sent from the ...
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(2010-04-12)Department: NeuroscienceFor two principle reasons, the transmembrane Met receptor tyrosine kinase has emerged as an important molecular target for study in the developing forebrain: 1) it regulates a variety of neurodevelopmental processes in ...
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(2011-08-11)Department: NeuroscienceThe Met receptor tyrosine kinase is capable of mediating several neurodevelopmental events in vitro, but its functions in vivo are incompletely understood. Three alleles in the 5’ regulatory region of the human ortholog, ...
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(2014-03-27)Department: NeuroscienceOptical imaging of intrinsic signals (OIS) has improved our understanding of the functional organization of the cerebral cortex. However, the technique places time constraints on experiments due to the averaging needed to ...
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(2011-12-12)Department: NeuroscienceSonic hedgehog (Shh) signaling regulates cell growth during embryonic development, tissue homeostasis and tumorigenesis. Concentration-dependent cellular responses to secreted Shh protein are essential for tissue patterning. ...
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(2016-07-27)Department: NeuroscienceAddiction is a disorder characterized by drug use despite negative consequences. Drugs of abuse hijack circuits within brain centers which evolved to respond to natural rewards such as palatable, calorie-dense foods. This ...
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(2020-11-03)Department: NeuroscienceAMPA receptors (AMPAR) are key mediators of fast excitatory neurotransmission within the brain. The functional identity of AMPAR at the synapses strongly contributes to molecular mechanisms of learning and memory. At the ...
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(2022-05-09)Department: NeuroscienceThis dissertation work comprises a functional characterization of R294X and representative C-terminal stop loss MECP2 mutations that cause Rett syndrome (RTT) in people. In Chapter 2, we show that RTT-like phenotypes induced ...
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(2024-03-11)Department: NeuroscienceThe posterior parietal cortex (PPC), generally refers to the part of parietal cortex posterior to Brodmann’s Areas 3, 1, and 2 of the somatosensory areas, is a prominent feature of primate brains. PPC emerged in early ...