Browsing Electronic Theses and Dissertations by Department "Neuroscience"
Now showing items 41-60 of 232
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(2011-09-13)Department: NeuroscienceExpansion in the glutamine encoding CAG triplet-repeat in the Huntingtin (HTT) gene causes Huntington’s disease (HD). The susceptibility, age of onset, and severity of HD is modified by ill-defined genetic and/or environmental ...
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(2014-04-09)Department: NeuroscienceGABA-ergic disturbances are hallmark features of many brain disorders. Two transgenic mouse lines were generated to suppress GAD1 in non-overlapping cell types that express cholecystokinin (CCK) or neuropeptide Y (NPY). ...
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(2008-01-02)Department: NeuroscienceMutations in the human K-Cl cotransporter-3 (KCC3) gene lead to a severe neurological disorder called peripheral neuropathy associated with agenesis of the corpus callosum (ACCPN). At the same time as that discovery, the ...
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(2011-12-08)Department: NeuroscienceAutism spectrum disorders (ASD) are characterized by disrupted social interactions, disordered language and communication, and restrictive interests and repetitive behaviors. Although not part of the main diagnostic ...
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(2015-03-25)Department: NeuroscienceApproximately 25% of individuals with autism spectrum disorder (ASD) possess elevated whole blood serotonin (5-HT) levels, termed hyperserotonemia. However, the connection between this biomarker and the pathophysiology of ...
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(2018-09-18)Department: NeuroscienceStress contributes to numerous psychiatric disorders. CRF signaling in the bed nucleus of the stria terminalis (BNST) drives negative affective behaviors, thus agents that decrease activity of these cells may be of therapeutic ...
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(2017-11-16)Department: NeuroscienceNeurons are specialized cells that communicate through electrochemical signals: a neuron receives input through dendrites and sends information through a single axon. The receptive field for each neuron is defined by sister ...
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(2020-03-25)Department: NeuroscienceThis study uses subjects’ electroencephalogram (EEG) and behavior to test an assumption underlying the Federal Rules of Evidence (FRE), the rules that determine what evidence juries hear, and an assumption in most cognitive ...
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(2008-02-26)Department: NeuroscienceDOPAMINE AND THE POSITIVELY REINFORCING PROPERTIES OF AGGRESSION MARIA H. COUPPIS Dissertation under the direction of Professor Craig H. Kennedy Aggression is a necessary behavioral response aimed at securing survival. ...
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(2011-12-04)Department: NeuroscienceEmbryonic dopamine (DA) receptor (DR) expression in the medial frontal cortex (mFC) coincides with the formation of neural circuits during the period of axon pathfinding but the signaling properties of DRs and their effect ...
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(2019-03-25)Department: NeuroscienceSubstance use disorders and depression are significant societal burdens. Both pathologies are associated with alterations of the nucleus accumbens (NAc), a reward center of the brain. The NAc is composed of two types of ...
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(2019-09-13)Department: NeuroscienceAcquisition and extinction of learned fear responses utilize flexible yet conserved neural circuits that promote or suppress fear expression, respectively. Here we show that acquisition of passive fear behavior is associated ...
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(2013-07-18)Department: NeuroscienceGABAA receptors are pentameric, ligand-gated chloride channels that mediate the majority of fast inhibition in the brain. Because they are assembled from an array of 19 subunit subtypes, GABAA receptors are remarkable ...
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(2022-06-15)Department: NeuroscienceHearing-in-noise is a complex auditory task that is critical for effective communication in the presence of competing sounds. Damage to the inner ear caused by noise exposure can alter the representation of sounds in the ...
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(2018-03-22)Department: NeuroscienceNEUROSCIENCE Electrophysiological Signatures of Multisensory Temporal Processing in the Human Brain David Michael Simon Dissertation under the direction of Professor Mark T. Wallace Events in the natural world frequently ...
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(2023-03-23)Department: NeuroscienceCentral nervous system (CNS) immune privilege is imparted by a complex set of mechanisms designed to protect the fragile brain tissue. Brain endothelial cells (BECs), the main functional unit of the blood-brain barrier ...
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(2022-03-04)Department: NeuroscienceThe suprachiasmatic nucleus (SCN) of the hypothalamus serves as a central circadian oscillator that receives direct retinal light input and synchronizes (or entrains) endogenous daily rhythms in behavior and physiology to ...
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(2019-12-04)Department: NeuroscienceManganese is an essential micronutrient, required for the activity of many enzymes. Our lab has established that cellular and mouse models of Huntington’s Disease (HD) exhibit reduced striatal Mn bioavailability. This ...
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(2008-07-18)Department: NeuroscienceMany neuropsychiatric disorders involve disruptions in emotional regulation that are correlated with dysfunctions in the limbic circuitry of the brain. Improved treatment and outcome of disorders of emotional regulation ...
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(2016-08-01)Department: NeuroscienceCannabinoid receptors have been examined as potential targets to alleviate the negative consequences of anxiety, trauma-related, and stress-related disorders. However, in preclinical animal studies, synthetic cannabinoids ...