Browsing Electronic Theses and Dissertations by Department "Biomedical Informatics"
Now showing items 41-60 of 131
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(2021-09-17)Department: Biomedical InformaticsMechanical Ventilation (MV) in the Neonatal Intensive Care Unit (NICU) is a life-saving therapy that is associated with multiple comorbidities. Compared to pressure-limited ventilation volume-targeted ventilation (VTV) is ...
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(2012-12-10)Department: Biomedical InformaticsThere is little research on how clinically relevant concepts are transferred from a patient, through a healthcare provider, and then to a resultant clinical note. This study tested whether clinical information flow, defined ...
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(2005-07-23)Department: Biomedical InformaticsTrait heterogeneity, which exists when a trait has been defined with insufficient specificity such that it is actually two or more distinct traits, has been implicated as a confounding factor in traditional statistical ...
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(2017-03-16)Department: Biomedical InformaticsThe spatial distribution of genetic variation within proteins is shaped by evolutionary constraint and thus can provide insights into the functional importance of protein regions and the potential pathogenicity of protein ...
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(2015-08-27)Department: Biomedical InformaticsThe aims of this project are 1) to evaluate various data sources and algorithms for identifying hypertensive individuals within the electronic health record, and 2) to develop and evaluate a novel method for identifying ...
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(2018-01-22)Department: Biomedical InformaticsPatterns of genetic variation along the human genome provide insight into functional and evolutionary constraints on different loci. Quantifying these patterns of constraint improves our ability to identify functional ...
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(2016-11-21)Department: Biomedical InformaticsThe widely used American Society of Anesthesiologist’s’ (ASA) Physical Status classification is subjective and requires time-consuming clinician assessment. Machine learning can be used to develop a system that predicts ...
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(2023-07-11)Department: Biomedical InformaticsPolygenic scores (PGS) aim to capture a person’s genetic predisposition to a disease or trait. There is substantial interest in applying PGS to clinical settings to identify patients at elevated risk for disease. Given its ...
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(2014-11-26)Department: Biomedical InformaticsElectronic Health Records (EHRs) allow for the digital capture of patient information and have proven to be a valuable tool for patient treatment. In this dissertation, I explore reuse of EHR data for clinical and genomic ...
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(2011-04-15)Department: Biomedical InformaticsPediatric asthma exacerbations account for >1.8 million ED visits annually. Guidelines can decrease variability in asthma treatment and improve clinical outcomes; however, guideline adherence is inadequate. We evaluated a ...
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(2013-04-08)Department: Biomedical InformaticsBIOMEDICAL INFORMATICS DESIGN AND IMPLEMENTATION OF A COMPUTERIZED INFORMATICS TOOL TO FACILITATE CLINICIAN ACCESS TO A STATE’S PRESCRIPTION DRUG MONITORING PROGRAM DATABASE STEVEN JOHN WHITE Thesis under the direction ...
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(2016-07-27)Department: Biomedical InformaticsBackground Effective medical software is designed to fit the needs of the end users, translating their work into action. User-centered design seeks to involve users at all stages of the design process, but the process ...
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(2006-04-17)Department: Biomedical InformaticsThis thesis describes the development and evaluation of a computerized algorithm for detecting patients with acute asthma exacerbations who present to a pediatric emergency department (ED). A rule-based algorithm was ...
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(2020-01-17)Department: Biomedical InformaticsThe phecode system was built upon the ICD-9-CM for PheWAS using the EHR. In this study, we developed and performed an initial evaluation of maps from ICD-10 and the ICD-10-CM codes to phecodes. We mapped ICD-10 and ICD-10-CM ...
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(2023-09-26)Department: Biomedical InformaticsThere is a critical need for high-throughput electronic health record (EHR) phenotyping tools designed for use in pediatric populations. Previous advances in EHR phenotyping have involved the development of phecodes that ...
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(2005-12-13)Department: Biomedical InformaticsUnwanted drug-drug interactions endanger millions of patients each year and burden families and the hospital system with escalating costs. Computer-based alerting systems are designed to prevent these interactions, yet the ...
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(2007-07-31)Department: Biomedical InformaticsMass Spectrometry (MS) is emerging as a breakthrough mass-throughput technology believed to have powerful potential for producing clinical diagnostic and prognostic models and for identifying relevant disease biomarkers. ...
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(2014-07-17)Department: Biomedical InformaticsA logical mechanism by which SNPs affect the pathophysiology of disease is through altering the expression of genes. Several studies have explored how SNPs alter expression of nearby genes (cis-eQTLs), but far fewer studies ...
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(2022-07-18)Department: Biomedical InformaticsSupporting public health research in identifying disease disparities and developing targeted interventions, as well as enabling the public’s situational awareness during a pandemic, requires regular dissemination of ...
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(2024-02-16)Department: Biomedical InformaticsAfter the 21st Century Cures Act (Cures Act) created penalties for blocking the delivery of information to patients, medical centers now release test results to patients immediately. VUMC achieved compliance with Cures Act ...