Browsing Electronic Theses and Dissertations by Department "Microbiology and Immunology"
Now showing items 21-40 of 126
-
(2019-06-27)Department: Microbiology and ImmunologyRecent advances in computational biology and sequencing technologies have led to the development of assays that generate a large number of measurements on a large number of samples (individuals or single cells). Experimental ...
-
(2017-02-28)Department: Microbiology and ImmunologyCatheter-associated urinary tract infections (CAUTIs) account for ~30% of hospital-acquired infections. Biofilm formation, a process where bacteria assume a temporary multicellular lifestyle, serves as a reservoir for ...
-
(2011-08-17)Department: Microbiology and ImmunologyIn metazoans, developmentally regulated genes depend upon cis-regulatory elements for cell-type specific and heritable transcription. By employing a BAC transgenic system, I demonstrate the function of the noncoding region ...
-
(2016-07-24)Department: Microbiology and ImmunologyAchieving transplant tolerance in the autoimmune environment will require targeting multiple immunologic dysregulations in T-B lymphocyte collaboration that drive the aggressive anti-graft response. At a biologic level, ...
-
(2013-12-04)Department: Microbiology and ImmunologyBloodstream spread is an essential step in the pathogenesis of many viruses. However, mechanisms that promote viremia are not well understood. Reoviruses are neurotropic viruses that disseminate systemically through the ...
-
(2015-03-26)Department: Microbiology and ImmunologyMy thesis project explores mechanisms of innate immune evasion by human metapneumovirus (HMPV), as well as the consequences of a lack of type I IFN (IFNAR) signaling on host response and pathogenesis. I show that the ...
-
(2016-03-04)Department: Microbiology and ImmunologyClostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. The two principle virulence factors, TcsH and TcsL, are highly homologous to C. difficile TcdA and TcdB, ...
-
(2007-03-14)Department: Microbiology and ImmunologyProtein synthesis is a complex and poorly understood process that requires the concerted activity of ribosomes and a plethora of trans-acting protein factors. This dissertation used proteomic, biochemical, and functional ...
-
(2004-12-12)Department: Microbiology and ImmunologyExperimental and epidemiological studies have suggested that the vacuolating cytotoxin (VacA) is an important H. pylori virulence factor that contributes to the development of peptic ulceration and gastric adenocarcinoma. ...
-
(2018-07-10)Department: Microbiology and ImmunologyViral nonstructural proteins, which are not packaged into virions, are essential for the replication of most viruses. Reovirus, a nonenveloped, double-stranded RNA (dsRNA) virus, encodes three nonstructural proteins that ...
-
(2018-08-22)Department: Microbiology and ImmunologyViral encephalitis is a serious and life-threatening inflammation of the central nervous system (CNS). However, mechanisms of viral neuroinvasion and disease pathogenesis in the CNS are often poorly understood. Mammalian ...
-
(2010-12-17)Department: Microbiology and ImmunologyCommon, complex diseases are not caused by a single gene mutation but rather have genetic and environmental components. As a subset, autoimmune diseases also possess robust gene expression signatures that have both genetic ...
-
(2019-05-08)Department: Microbiology and ImmunologyAdverse reactions to drugs are a threat to individual safety and quality of life. Two of the severest reactions, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and Drug Reaction with Eosinophilia and Systemic ...
-
(2020-01-14)Department: Microbiology and ImmunologyInvading microbial pathogens must sense and respond to the hostile environment of the vertebrate host to survive and cause infection. Clostridioides difficile, formerly Clostridium difficile, is the leading cause of ...
-
(2019-01-25)Department: Microbiology and ImmunologyThe cofactor heme is essential to the growth and virulence of the human pathogen Staphylococcus aureus. S. aureus is capable of synthesizing heme de novo as well as acquiring it from host hemoglobin. The molecular mechanisms ...
-
(2019-03-20)Department: Microbiology and ImmunologyHIV-1 infection depends on efficient intracytoplasmic transport of the incoming viral core to the target cell nucleus. Evidence suggests that this movement is facilitated by the microtubule motor dynein, a large multi-protein ...
-
(2018-04-02)Department: Microbiology and ImmunologyAnnual outbreaks of influenza A viruses in humans are one of the major health problems worldwide, causing more than 250,000 deaths every year. In addition to yearly epidemics, novel influenza viruses that cross the species ...
-
(2011-06-09)Department: Microbiology and ImmunologyMICROBIOLOGY AND IMMUNOLOGY HUMAN HEMOGLOBIN AS AN IRON SOURCE OF STAPHYLOCOCCUS AUREUS GLIB PISHCHANY Dissertation under the direction of Professor Eric P. Skaar Staphylococcus aureus is a tremendous human pathogen ...
-
(2007-04-17)Department: Microbiology and ImmunologyVirus cell entry is a multi-step process that often requires independent receptors for attachment and internalization. Reovirus infection is initiated by attachment to cell-surface carbohydrate and junctional adhesion ...
-
(2009-02-10)Department: Microbiology and ImmunologyUncoating of the viral core following penetration into the target cell represents a fundamentally obscure step in the HIV-1 life cycle. Our laboratory has previously reported that mutations in the CA protein that positively ...