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Dual roles for the ER Membrane Protein Complex in Flavivirus Infection: Viral Entry and Protein Biogenesis
(SCIENTIFIC REPORTS, 2019-07-04)
Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue ...
Value-driven attentional capture enhances distractor representations in early visual cortex
(PLOS Biology, 2019-08)
When a behaviorally relevant stimulus has been previously associated with reward, behavioral responses are faster and more accurate compared to equally relevant but less valuable stimuli. Conversely, task-irrelevant stimuli ...
Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection
(PLOS Pathogens, 2019-06)
Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal ...
Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis
(International Journal of Moledular Sciences, 2019-06-01)
The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
3D Co-culture of hiPSC-Derived Cardiomyocytes With Cardiac Fibroblasts Improves Tissue-Like Features of Cardiac Spheroids
(Frontiers in Molecular Biosciences, 2020-02-14)
Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac development, function, and remodeling. Properties of 3D co-cultures are incompletely understood. Hence, 3D co-culture of cardiomyocytes ...
Imaging Cataract-Specific Peptides in Human Lenses
(Cells, 2023-01-13)
Age-related protein truncation is a common process in long-lived proteins such as proteins found in the ocular lens. Major truncation products have been reported for soluble and membrane proteins of the lens, including ...
The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10
(Open Biology, 2019-08)
Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor ...
Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells
(Journal of Biological Chemistry, 2019-04-19)
Oxidative modifications of cysteine residues are an important component in signaling pathways, enzymatic regulation, and redox homeostasis. Current direct and indirect methods detect specific modifications and a general ...
p73 regulates epidermal wound healing and induced keratinocyte programming
(Plos One, 2019-06-19)
p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal ...
Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation
(Frontiers in Microbiology, 2019-08-29)
Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome. Orisomes perform two ...