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Antigen receptor control of methionine metabolism in T cells
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study ...
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
(NATURE COMMUNICATIONS, 2019-07-10)
TFF1, a secreted protein, plays an essential role in keeping the integrity of gastric mucosa and its barrier function. Loss of TFF1 expression in the TFF1-knockout (KO) mouse leads to a pro-inflammatory phenotype with a ...