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Universal Influenza Vaccination Among Healthcare Personnel: Yes We Should
(OPEN FORUM INFECTIOUS DISEASES, 2019-04)
lBromodomain inhibitor JQ1 reversibly blocks IFN-gamma production
(Scientific Reports, 2019-07-16)
As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...
Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli
(MBIO, 2019-03)
Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these components lends spatial organization to ...
Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype
(MBIO, 2019-05)
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma; however, most infected individuals never develop this malignancy. Strain-specific microbial factors, such as the oncoprotein CagA, as well as ...
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
(NATURE COMMUNICATIONS, 2019-07-10)
TFF1, a secreted protein, plays an essential role in keeping the integrity of gastric mucosa and its barrier function. Loss of TFF1 expression in the TFF1-knockout (KO) mouse leads to a pro-inflammatory phenotype with a ...
Identification of a Pro-angiogenic Functional Role for FSP1-positive Fibroblast Subtype in Wound Healing
(NATURE COMMUNICATIONS, 2019-07-09)
Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a ...
Interchromosomal Translocations as a Means to Map Chromosome Territories in Breast Cancer
(Cancer Iinformatics, 2019-04-16)
The genome-wide identification of mutated genes is an important advance in our understanding of tumor biology, but several fundamental questions remain open. How do these genes act together to promote cancer development ...
Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features
(PLOS COMPUTATIONAL BIOLOGY, 2019-04)
The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to ...
Identification of Potential Virulence Factors in the Model Strain Acinetobacter baumannii A118
(FRONTIERS IN MICROBIOLOGY, 2019-07-23)
Acinetobacter baumannii A118, a strain isolated from the blood of an infected patient, is naturally competent and unlike most clinical strains, is susceptible to a variety of different antibiotics including those usually ...
Antigen receptor control of methionine metabolism in T cells
(eLife, 2019-03-27)
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study ...