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Autologous Chondrocyte Grafting Promotes Bone Formation in the Posterolateral Spine

dc.contributor.authorSielatycki, J. Alex
dc.contributor.authorSaito, Masanori
dc.contributor.authorYuasa, Masato
dc.contributor.authorMoore-Lotridge, Stephanie N.
dc.contributor.authorUppuganti, Sasidhar
dc.contributor.authorColazo, Juan M.
dc.contributor.authorHysong, Alexander A.
dc.contributor.authorRobinette, J. Patton
dc.contributor.authorOkawa, Atsushi
dc.contributor.authorYoshii, Toshitaka
dc.contributor.authorSchwartz, Herbert S.
dc.contributor.authorNyman, Jeffry S.
dc.contributor.authorSchoenecker, Jonathan G.
dc.identifier.citationSielatycki, J. A., Saito, M., Yuasa, M., Moore‐Lotridge, S. N., Uppuganti, S., Colazo, J. M., … Schoenecker, J. G. (2018). Autologous chondrocyte grafting promotes bone formation in the posterolateral spine. JOR SPINE, 1(1), e1001.
dc.description.abstractPseudarthrosis following spinal fusion remains problematic despite modern surgical and grafting techniques. In surgical spinal fusion, new bone forms via intramembranous and endochondral ossification, with endochondral ossification occurring in the hypoxic zones of the fusion bed. During bone development and fracture healing, the key cellular mediator of endochondral ossification is the hypertrophic chondrocyte given its ability to function in hypoxia and induce neovascularization and ossification. We therefore hypothesize that hypertrophic chondrocytes may be an effective bone graft alternative.en_US
dc.subjectBone Formationen_US
dc.subjectBone-Morphogenic Proteinen_US
dc.subjectFracture Callusen_US
dc.subjectHypertrophic Chondrocytesen_US
dc.subjectIliac Crest Bone Graften_US
dc.subjectPosterolateral Spinal Fusionen_US
dc.subject.lcshVascular endothelial growth factorsen_US
dc.titleAutologous Chondrocyte Grafting Promotes Bone Formation in the Posterolateral Spineen_US
dcterms.rights© 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US

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