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Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance
(Molecular Metabolism, 2023-01-13)
Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that ...
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
(Communications Biology, 2023-01-13)
Independent studies demonstrate the significance of gut microbiota on the pathogenesis of chronic lung diseases; yet little is known regarding the role of the gut microbiota in lung fibrosis progression. Here we show, using ...
Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma
(Cell Death & Disease, 2023-01-16)
Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor and its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, the mechanisms underlying genomic, transcriptomic ...
When Blood Pressure Increases with Standing: Consensus Definition for Diagnosing Orthostatic Hypertension
(Blood Pressure, 2023-01-03)
Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG
(Frontiers In Microbiology, 2023-01-04)
IntroductionIntestinal epithelial cells (IECs) provide the frontline responses to the gut microbiota for maintaining intestinal homeostasis. Our previous work revealed that IEC-derived components promote the beneficial ...
Review Paper on Penetrating Brain Injury Ethical Quandaries in the Trauma Bay and Beyond
(Annals Of Surgery, 2023-01-28)
Objective:The aim of this review was to review the ethical and multidisciplinary clinical challenges facing trauma surgeons when resuscitating patients presenting with penetrating brain injury (PBI) and multicavitary trauma. ...
Suicide and other causes of death among Chernobyl cleanup workers from Estonia, 1986-2020: an update
(European Journal Of Epidemiology, 2023-01-07)
Mortality was studied in a cohort of 4831 men from Estonia who participated in the environmental cleanup of the radioac-tively contaminated areas around Chernobyl in 1986-1991. Their mortality in 1986-2020 was compared ...
Pulmonary Hypertension Association's 2022 International Conference Scientific Sessions Overview
(Pulmonary Circulation, 2023-01-11)
The considerable progress made in recent years in the diagnosis, risk stratification, and treatment of pulmonary hypertension was highlighted during the most recent edition of the Pulmonary Hypertension Association Scientific ...
Myeloid Phenotypes in Tracheostomy-Associated Granulation Tissue
(Laryngoscope, 2023-01-21)
Objective(s):Tracheostomy-associated granulation tissue is a common, recurrent problem occurring secondary to chronic mucosal irritation. Although granulation tissue is composed of predominantly innate immune cells, the ...
Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment
(Blood Cancer Journal, 2023-01-04)
Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones caused by the acquisition of somatic point mutations or mosaic chromosomal alterations (mCAs). Clonal hematopoiesis caused by somatic ...