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The Anti-Proliferative and Anti-Invasive Effect of Leaf Extracts of Blueberry Plants Treated with Methyl Jasmonate on Human Gastric Cancer In Vitro Is Related to Their Antioxidant Properties
(Antioxidants, 2020-01)
Gastric cancer is the third main cause of cancerous tumors in humans in Chile. It is well-accepted that a diet rich in antioxidant plants could help in fighting cancer. Blueberry is a fruit crop with a high content of ...
Pharmacokinetic-tailored approach to hemophilia prophylaxis__Medical decision making and outcomes
(Research and Practice in Thrombosis and Haemostasis, 2020-02)
Background Clinical application of population pharmacokinetics (popPK) is of increasing interest to patients with hemophilia, providers, and payers. Routine use of popPK profiles in factor replacement prophylaxis decision ...
Mislocalized cytoplasmic p27 activates PAK1-mediated metastasis and is a prognostic factor in osteosarcoma
(Molecular Oncology, 2020-02)
The development of pulmonary metastasis is the leading cause of death in osteosarcoma (OS), which is the most common malignant bone tumor in children. We have previously reported that the tumor suppressor p27 (KIP1, CDKN1B) ...
P-31 magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
(NMR in Biomedicine, 2020-02)
Skeletal muscle phosphorus-31 P-31 MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of P-31 MRS in skeletal muscle depend on the research question, and to assess ...
Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci
(Drug and Alcohol Dependence, 2020-01)
Background: Little is known about the functional mechanisms through which genetic loci associated with substance use traits ascertain their effect. This study aims to identify and functionally annotate loci associated with ...
Effects of fibre-rich rye milling fraction on the functional properties and nutritional quality of wholemeal rye bread
(Journal of Food Science and Technology-Mysore, 2020-01)
The goal was to assess the effects of partial replacement of wholemeal rye flour with 30%, 40% and 50% of the high-fibre rye flour (HFRF) on nutritional quality and sensory and physicochemical characteristics of breads. ...
Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains
(Journal of Infectious Diseases, 2020-03-01)
Background. Multiple factors influence the human immunodeficiency virus (HIV) antibody response produced during natural infection, leading to responses that can vary in specificity, strength, and breadth.
Methods. People ...
A review of published anticholinergic scales and measures and their applicability in database analyses
(Archives of Gerontogy and Geriatrics, 2020-03)
Background/objectives: Available metrics for characterizing cumulative anticholinergic exposure over time may not be well suited for use across all US data sources. In this review, the properties of existing anticholinergic ...
The 2019 Schizophrenia International Research Society Conference, 10-14 April, Orlando, Florida: A summary of topics and trends
(Psychiatry Research, 2020-02)
The Schizophrenia International Research Society (SIRS) recently held its first North American congress, which took place in Orlando, Florida from 10-14 April 2019. The overall theme of this year's congress was United in ...