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Identification of a Pro-angiogenic Functional Role for FSP1-positive Fibroblast Subtype in Wound Healing
(NATURE COMMUNICATIONS, 2019-07-09)
Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Differential Interaction of Peripheral Blood Lymphocyte Counts (ALC) With Different in vivo Depletion Strategies in Predicting Outcomes of Allogeneic Transplant: An International 2 Center Experience
(FRONTIERS IN ONCOLOGY, 2019-07-10)
Dosing regimens for antithymocyte globulin (ATG) and anti-CD52 antibody (alemtuzumab) for graft vs. host disease prophylaxis (GVHD) are empiric or weight-based, and do not account for individual patient factors. Recently, ...
Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype
(MBIO, 2019-05)
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma; however, most infected individuals never develop this malignancy. Strain-specific microbial factors, such as the oncoprotein CagA, as well as ...
Challenges and Strategies for Improving Training of Mid-Level Research Personnel in Nigeria
(Annals of Global Health, 2019-06)
Background: Contextual research evidence is needed to reduce morbidity and mortality due to chronic but preventable diseases in low- and middle-income countries. Nigeria, Africa's most populous country, is particularly ...
Metabolic Effects of Bile Acids: Potential Role in Bariatric Surgery
(Cellular and Molecular Gastroenterology and Hepatology, 2019)
Bariatric surgery is the most effective and durable treatment for morbid obesity, with an unexplained yet beneficial side effect of restoring insulin sensitivity and improving glycemia, often before weight loss is observed. ...
Employment Opportunities and Experiences among Recent Master's-Level Global Health Graduates
(Annals of Global Health, 2019)
Objectives: To examine the job search, employment experiences, and job availability of recent global health-focused master's level graduates.
Methods: An online survey was conducted from October to December 2016 based ...
Variation and selection on codon usage bias across an entire subphylum
(PLOS Genetics, 2019-07)
Variation in synonymous codon usage is abundant across multiple levels of organization: between codons of an amino acid, between genes in a genome, and between genomes of different species. It is now well understood that ...
A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression
(PLOS Genetics, 2019-07)
Major depression is a common and severe psychiatric disorder with a highly polygenic genetic architecture. Genome-wide association studies have successfully identified multiple independent genetic loci that harbour variants ...
Racial disparities in end-stage renal disease in a high-risk population_the Southern Community Cohort Study
(BMC Nephrology, 2019-08-07)
Introduction The Southern Community Cohort Study is a prospective study of low socioeconomic status (SES) blacks and whites from the southeastern US, where the burden of end-stage renal disease (ESRD) and its risk factors ...