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Feasibility and acceptability of telephone-delivered cognitive-behavioral-based physical therapy for patients with traumatic lower extremity injury
(Journal of Applied Biobeahvioral Research, 2019-06)
Purpose To determine feasibility and acceptability of a telephone-based Cognitive-Behavioral-Based Physical Therapy program for patients following traumatic lower extremity injury (CBPT-Trauma). Methods Patients were ...
Graphene-Based Nanomaterials: From Production to Integration With Modern Tools in Neuroscience
(2019-07-16)
Graphene, a two-dimensional carbon crystal, has emerged as a promising material for sensing and modulating neuronal activity in vitro and in vivo. In this review, we provide a primer for how manufacturing processes to ...
A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids
(Frontiers in Genetics, 2019-06-12)
Uterine fibroids affect up to 77% of women by menopause and account for up to $34 billion in healthcare costs each year. Although fibroid risk is heritable, genetic risk for fibroids is not well understood. We conducted a ...
The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population
(Respiratory Reserarch, 2019-06-10)
BackgroundSingle birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and ...
Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia A Pooled Analysis of More Than 1 Million Participants
(JAMA Network Open, 2019-04)
IMPORTANCE Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations.
OBJECTIVES ...
Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users
(JAMA Network Open, 2019-06)
IMPORTANCE Implementation of pharmacogenetic testing to guide drug prescribing has potential to improve drug response and prevent adverse events. Robust data exist for more than 30 gene-drug pairs linking genotype to drug ...
A novel system for introducing precisely-controlled, unanticipated gait perturbations for the study of stumble recovery
(Journal of Neuroengineering and Rehabiliation, 2019-06-20)
BackgroundThe experimental study of stumble recovery is essential to better understanding the reflexive mechanisms that help prevent falls as well as the deficiencies in fall-prone populations. This study would benefit ...
IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells
(Molecular Genetrics & Genome Medicine, 2019-06)
BackgroundFamily screening of a 48-year-old male with recently diagnosed IgG4-related disease (IgG4-RD) revealed unanticipated elevations in plasma IgG4 in his two healthy teenaged sons.
MethodsWe performed gene sequencing, ...
Peroxidasin Is a Novel Target of Autoantibodies in Lupus Nephritis
(Kidiney International Reports, 2019-07)
Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI
(Arteriosclerosis Thrombosis and Vascular Biology, 2019-07)
Objective- Activation of coagulation FXI (factor XI) by FXIIa (activated factor XII) is a prothrombotic process. The endothelium is known to play an antithrombotic role by limiting thrombin generation and platelet activation. ...