Now showing items 1-10 of 273
Universal Influenza Vaccination Among Healthcare Personnel: Yes We Should
(OPEN FORUM INFECTIOUS DISEASES, 2019-04)
Factors Associated with Perioperative Mortality in Typhoid Fever Patients with Intestinal Perforation in Nigeria
(Integrative Journal of Global Health, 2017)
Objective: Despite the availability of effective antibiotic treatment, patients in Nigeria continue to perish from complications of typhoid fever, including intestinal perforations. Given the preventable nature of these ...
Bone Fracture Acute Phase Response—A Unifying Theory of Fracture Repair: Clinical and Scientific Implications
Bone fractures create five problems that must be resolved: bleeding, risk of infection, hypoxia, disproportionate strain, and inability to bear weight. There have been enormous advancements in our understanding of the ...
Novel Preclinical Murine Model of Trauma-Induced Elbow Stiffness
Peri-articular injury may result in functional deficits and pain. In particular, post-traumatic elbow stiffness is a debilitating condition, precluding patients from performing activities of daily living. As such, clinicians ...
Phase II Trial of AKT Inhibitor MK-2206 in Patients With Advanced Breast Cancer Who Have Tumors With PIK3CA or AKT Mutations, and/or PTEN loss/PTEN Mutation
(BREAST CANCER RESEARCH, 2019-07-05)
BackgroundThe PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer. We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer ...
Identification of a Pro-angiogenic Functional Role for FSP1-positive Fibroblast Subtype in Wound Healing
(NATURE COMMUNICATIONS, 2019-07-09)
Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Leclercia adecarboxylata Musculoskeletal Infection in an Immune Competent Pediatric Patient: An Emerging Pathogen?
Case: An immune competent pediatric patient presented with a persistent lower extremity infection with Leclercia adecarboxylata after a penetrating injury. This case report details the presentation, clinical course, and ...
A Subdermal Osteochondroma in a Young Girl
Osteochondromas are common benign tumors of cartilage and bone. They are usually found as contiguous bone with a cartilage cap at the end of the growth plate of long bones. Similar to structure are extraskeletal osteochondromas. ...
Progression and Pathology of Traumatic Optic Neuropathy From Repeated Primary Blast Exposure
(FRONTIERS IN NEUROSCIENCE, 2019-07-11)
Indirect traumatic optic neuropathy (ITON) is a condition that is often associated with traumatic brain injury and can result in significant vision loss due to degeneration of retinal ganglion cell (RGC) axons at the time ...