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Juvenile idiopathic arthritis associated with a mutation in GATA3
(Arthritis Research & Therapy, 2019-06-25)
BackgroundGATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. ...
lBromodomain inhibitor JQ1 reversibly blocks IFN-gamma production
(Scientific Reports, 2019-07-16)
As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...
Juvenile idiopathic arthritis associated with a mutation in GATA3
(Arthritis Research & Therapy, 2019-06-25)
BackgroundGATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. ...