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Effects of Interleukin-1 beta Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk A Secondary Analysis of CANTOS
(Hypertension, 2020-02)
While hypertension and inflammation are physiologically inter-related, the effect of therapies that specifically target inflammation on blood pressure is uncertain. The recent CANTOS (Canakinumab Anti-inflammatory Thrombosis ...
Neural representations of phonology in temporal cortex scaffold longitudinal reading gains in 5-to 7-year-old children
(Neuroimage, 2020-02-15)
The objective of this study was to investigate whether phonological processes measured through brain activation are crucial for the development of reading skill (i.e. scaffolding hypothesis) and/or whether learning to read ...
Coming to "Grp(s)" with Senescence in the Alveolar Epithelium
(American Journal of Respiratory and Critical Care Medicine, 2020-01-15)
Trends in Incidence of Methicillin-resistant Staphylococcus aureus Bloodstream Infections Differ by Strain Type and Healthcare Exposure, United States, 2005-2013
(Clinical Infectiouis Diseases, 2020-01-01)
Background. Previous reports suggested that US methicillin-resistant Staphylococcus aureus (MRSA) strain epidemiology has changed since the rise of USA300 MRSA. We describe invasive MRSA trends by strain type.
Methods. ...
Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation
(Neurobiology of Disease, 2020-02)
Over 1250 mutations in SCN1A, the Navl.1 voltage-gated sodium channel gene, are associated with seizure disorders including GEES +. To evaluate how a specific mutation, independent of genetic background, causes seizure ...
Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma
(Neurobiology of Disease, 2020-02)
Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to ...
Frequency Following Response and Speech Recognition Benefit for Combining a Cochlear Implant and Contralateral Hearing Aid
(Trends in Hearing, 2020-01)
Multiple studies have shown significant speech recognition benefit when acoustic hearing is combined with a cochlear implant (CI) for a bimodal hearing configuration. However, this benefit varies greatly between individuals. ...
Community Determinants of Physical Growth and Cognitive Development among Indian Children in Early Childhood: A Multivariate Multilevel Analysis
(International Journal of Environmental Research and Public Health, 2020-01)
Inadequate child physical growth and cognitive development share common individual-level risk factors. Less understood is how outcomes co-cluster at the community level and to what extent certain community-level characteristics ...
Does the magnetization transfer effect bias chemical exchange saturation transfer effects? Quantifying chemical exchange saturation transfer in the presence of magnetization transfer
(Maganetic Resonance in Medicine, 2020-09)
Purpose Chemical exchange saturation transfer (CEST) is an MRI technique sensitive to the presence of low-concentration solute protons exchanging with water. However, magnetization transfer (MT) effects also arise when ...