Browsing Vanderbilt University Medical Center by Title
Now showing items 34-53 of 315
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(NEPHROLOGY DIALYSIS TRANSPLANTATION, 2019-05)Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance dialysis. The burden of ...
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(Frontiers in Immunology, 2019-08-13)Multiple effector layers in the immune system ensure an optimal temporal and spatial distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive CD8(+) T lymphocytes (CTL) interact to elicit ...
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(NUCLEIC ACIDS RESEARCH, 2019-05)The t(8;21) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). We found that t(8; 21) AML were extremely sensitive to THZ1, which triggered apoptosis after only 4 h. We ...
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(Annals of Global Health, 2019-06)Background: Contextual research evidence is needed to reduce morbidity and mortality due to chronic but preventable diseases in low- and middle-income countries. Nigeria, Africa's most populous country, is particularly ...
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(BMJ Open, 2019-06)Objectives (1) To compare changes in vulnerability after hospital discharge among older patients with cardiovascular disease who were discharged home with self-care versus a home healthcare (HHC) referral and (2) to examine ...
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(Respiratory Reserarch, 2019-06-10)BackgroundSingle birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and ...
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(Annals of Clinical and Translational Neurology, 2020-01)Background We determined the association between ratios of plasma ceramide species of differing fatty-acyl chain lengths and incident dementia and Alzheimer's disease (AD) dementia in a large, community-based sample. Methods ...
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(Journal of the American Heart Association, 2019-12-03)Background The New York Heart Association (NYHA) classification has served as a fundamental tool for risk stratification of heart failure (HF) and determines clinical trial eligibility and candidacy for drugs and devices. ...
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(PLOS Medicine, 2019-07)Background In high-burden settings, case fatality rates are reported to be between 11% and 32% in hospitalized patients with HIV-associated tuberculosis, yet the underlying causes of mortality remain poorly characterized. ...
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(NPJ Breast Cancer, 2019-07-25)TP53 mutations are common in breast cancer and are typically associated with more aggressive tumor characteristics, but little is known about the clinicopathological and epidemiological relevance of p53 protein expression, ...
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(Molecular Genetics and Metabolism Reports, 2019-06)Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease mainly caused by a deficiency of arylsulfatase A activity. The typical clinical course of patients with the late infantile form includes ...
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(Clinicnal Case Reports, 2019-08)We report a case of noninfectious vacuolar interface dermatitis associated with colonic and perianal ulceration in a patient with acquired immunodeficiency syndrome (AIDS), which responded to immunosuppressive treatment. ...
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(Journal for Immunotherapy of Cancer, 2019-08-14)Background Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, we combined radiotherapy with immune checkpoint inhibition ...
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(American Journal of Respiratory and Critical Care Medicine, 2020-01-15)
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(International Journal of Environmental Research and Public Health, 2020-01)Inadequate child physical growth and cognitive development share common individual-level risk factors. Less understood is how outcomes co-cluster at the community level and to what extent certain community-level characteristics ...
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(Neurobiology of Disease, 2020-02)Over 1250 mutations in SCN1A, the Navl.1 voltage-gated sodium channel gene, are associated with seizure disorders including GEES +. To evaluate how a specific mutation, independent of genetic background, causes seizure ...
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(Internatinal Journal of Audiology, 2019-09)Objective: Provide recommendations to audiologists for the management of children with unilateral hearing loss (UHL) and for needed research that can lend further insight into important unanswered questions. Design: An ...
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(AMERICAN JOURNAL OF EPIDEMIOLOGY, 2019-06)The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS ...
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(Medicine, 2019-06)Studies investigating the association between transforming growth factor (TGF-beta-509C/T, rs1800469) promoter polymorphism and myocardial infarction (MI) risk reported inconsistent results. The aim of our study was to ...
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(BJPsych Open, 2019-01)Background As depression has a recurrent course, relapse and recurrence prevention is essential. Aims In our randomised controlled trial (registered with the Nederlands trial register, identifier: NTR1907), we ...