Browsing Vanderbilt University Medical Center by Title
Now showing items 193-212 of 315
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(NMR in Biomedicine, 2020-02)Skeletal muscle phosphorus-31 P-31 MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of P-31 MRS in skeletal muscle depend on the research question, and to assess ...
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(Genetics Medicine, 2019-08)Purpose: Haploinsufficiency of USP7, located at chromosome 16p13.2, has recently been reported in seven individuals with neurodevelopmental phenotypes, including developmental delay/intellectual disability (DD/ID), autism ...
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(American Journal of Respiratory and Critical Care Medicine, 2019-07-15)Over the past decade, several large registries of patients with idiopathic pulmonary fibrosis (IPF) have been established. These registries are collecting a wealth of longitudinal data on thousands of patients with this ...
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(Journal of the American Heart Association, 2019-05-07)Background-PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors effectively lower LDL (low-density lipoprotein) cholesterol and have been shown to reduce cardiovascular outcomes in high-risk patients. We used ...
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(Journal of Autism and Developmental Disorders, 2019-08)A randomized, 13-weeks, placebo-controlled double-blind study in 125 subjects aged 2-17.5years with Autism Spectrum Disorder or Smith-Magenis syndrome and insomnia demonstrated efficacy and safety of easily-swallowed ...
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(International Journal of Nanomedicine, 2020)Background: Helper T cell activity is dysregulated in a number of diseases including those associated with rheumatic autoimmunity. Treatment options are limited and usually consist of systemic immune suppression, resulting ...
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(Microsurgery, 2020-02)Background Peripheral nerve damage resulting in pain, loss of sensation, or motor function may necessitate a reconstruction with a bridging material. The RANGER (R) Registry was designed to evaluate outcomes following nerve ...
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(Kidiney International Reports, 2019-07)
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(Research and Practice in Thrombosis and Haemostasis, 2020-02)Background Clinical application of population pharmacokinetics (popPK) is of increasing interest to patients with hemophilia, providers, and payers. Routine use of popPK profiles in factor replacement prophylaxis decision ...
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(British Journal of Cancer, 2019-08-27)
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(Blood Cancer Journal, 2019-03-29)This phase I dose-escalation/expansion study evaluated isatuximab (anti-CD38 monoclonal antibody) monotherapy in patients with relapsed/refractory multiple myeloma (RRMM). Patients progressing on or after standard therapy ...
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(BREAST CANCER RESEARCH, 2019-07-05)BackgroundThe PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer. We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer ...
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(Annals of Oncology, 2019-07)Background ASP8273, a novel, small molecule, irreversible tyrosine kinase inhibitor (TKI) specifically inhibits the epidermal growth factor receptor (EGFR) in patients with activating mutations or EGFR T790M resistance ...
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Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness (Human Molecular Genetics, 2019-11-15)Humans are social animals that experience intense suffering when they perceive a lack of social connection. Modern societies are experiencing an epidemic of loneliness. Although the experience of loneliness is universally ...
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(MBIO, 2019-07)Phylosymbiosis is defined as microbial community relationships that recapitulate the phylogeny of hosts. As evidence for phylosymbiosis rapidly accumulates in different vertebrate and invertebrate holobionts, a central ...
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(Annals of the American Thoracic Society, 2019-07)To the Editor: Idiopathic pulmonary fibrosis (IPF) is a debilitating, progressive, fatal, fibrosing lung disease (1, 2). Pirfenidone and nintedanib are oral antifibrotics with demonstrated efficacy in reducing lung ...
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(Lancet Global Health, 2020)Background Heart failure is a global public health problem, affecting a large number of individuals from low-income and middle-income countries. REPORT-HF is, to our knowledge, the first prospective global registry collecting ...
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(Drug and Alcohol Dependence, 2020-01)Background: Little is known about the functional mechanisms through which genetic loci associated with substance use traits ascertain their effect. This study aims to identify and functionally annotate loci associated with ...
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(2018-02-19)Posttraumatic proximal radioulnar synostosis (PPRUS) is a severe complication of radial head and neck fractures known to occur after severe injury or operative fixation. Cases of PPRUS occurring after minimally displaced, ...
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(PLOS COMPUTATIONAL BIOLOGY, 2019-04)The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to ...