Delivery of Nanoparticles to Brain Metastases of Breast Cancer Using a Cellular Trojan Horse

dc.contributor.author	Choi, Mi-Ran
dc.contributor.author	Bardhan, Rizia
dc.contributor.author	Stanton-Maxey, Katie
dc.contributor.author	Badve, Sunil
dc.contributor.author	Nakshatri, Harikrishna
dc.contributor.author	Stantz, Keith M.
dc.contributor.author	Cao, Ning
dc.contributor.author	Halas, Naomi J.
dc.contributor.author	Clare, Susan E.
dc.date.accessioned	2018-04-02T15:49:42Z
dc.date.available	2018-04-02T15:49:42Z
dc.date.issued	2012-12
dc.identifier.issn	1868-6958
dc.identifier.uri	http://hdl.handle.net/1803/8804
dc.description.abstract	As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood–brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Springer	en_US
dc.subject	Breast Cancer	en_US
dc.subject	Brain Metastasis	en_US
dc.subject	Gold-silica Nanoshell	en_US
dc.subject	Nanoparticle	en_US
dc.subject	Blood–brain Barrier	en_US
dc.subject.lcsh	Cancer--Research	en_US
dc.title	Delivery of Nanoparticles to Brain Metastases of Breast Cancer Using a Cellular Trojan Horse	en_US
dc.type	Article	en_US
dc.identifier.doi	10.1007/s12645-012-0029-9