dc.contributor.author | Gobert, Alain P. | |
dc.contributor.author | Asim, Mohammad | |
dc.contributor.author | Smith, Thaddeus M. | |
dc.contributor.author | Williams, Kamery J. | |
dc.contributor.author | Barry, Daniel P. | |
dc.contributor.author | Allaman, Margaret M. | |
dc.contributor.author | McNamara, Kara M. | |
dc.contributor.author | V. Hawkins, Caroline | |
dc.contributor.author | Delgado, Alberto G. | |
dc.contributor.author | Piazuelo, M. Blanca | |
dc.contributor.author | Rathmacher, John A. | |
dc.contributor.author | Wilson, Keith T. | |
dc.date.accessioned | 2023-03-02T15:37:29Z | |
dc.date.available | 2023-03-02T15:37:29Z | |
dc.date.issued | 2022-12-06 | |
dc.identifier.citation | Gobert AP, Asim M, Smith TM, Williams KJ, Barry DP, Allaman MM, McNamara KM, Hawkins CV, Delgado AG, Blanca Piazuelo M, Rathmacher JA, Wilson KT. The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori. Biomed Pharmacother. 2023 Feb;158:114092. doi: 10.1016/j.biopha.2022.114092. Epub 2022 Dec 6. PMID: 36493697; PMCID: PMC9879697. | en_US |
dc.identifier.issn | 0753-3322 | |
dc.identifier.other | eISSN 1950-6007 | |
dc.identifier.other | PubMed ID36493697 | |
dc.identifier.uri | http://hdl.handle.net/1803/18045 | |
dc.description.abstract | Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. Dicar-bonyl electrophiles are generated from lipid peroxidation during the inflammatory response and form covalent adducts with amine-containing macromolecules. 2-hydroxybenzylamine (2-HOBA) is a natural compound derived from buckwheat seeds and acts as a potent scavenger of reactive aldehydes. Our goal was to investigate the effect of 2-HOBA on the pathogenesis of H. pylori infection. We used transgenic FVB/N insulin-gastrin (INS -GAS) mice as a model of gastric cancer. First, we found that 2-HOBA is bioavailable in the gastric tissues of these mice after supplementation in the drinking water. Moreover, 2-HOBA reduced the development of gastritis in H. pylori-infected INS-GAS mice without affecting the bacterial colonization level in the stomach. Further, we show that the development of gastric dysplasia and carcinoma was significantly reduced by 2-HOBA. Concom-itantly, DNA damage were also inhibited by 2-HOBA treatment in H. pylori-infected mice. In parallel, DNA damage was inhibited by 2-HOBA in H. pylori-infected gastric epithelial cells in vitro. In conclusion, 2-HOBA, which has been shown to be safe in human clinical trials, represents a promising nutritional compound for the chemoprevention of the more severe effects of H. pylori infection.
Keywords | en_US |
dc.description.sponsorship | This work was funded by NIH Grants R41CA257262 (K.T.W. and J.A. R.) P01CA116087 (K.T.W.) , P01CA028842 (K.T.W.) , and R01DK128200 (K.T.W.) , Department of Defense Grant W81XWH-21-1-0617 (K.T.W.) ; Veterans Affairs Merit Review Grant I01CX002171 (K.T.W.) , the Thomas F. Frist Sr. Endowment (K.T.W.) , and the Vanderbilt Center for Mucosal Inflammation and Cancer (K.T.W.) . | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Biomedicine & Pharmacotherapy | en_US |
dc.rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
dc.source.uri | https://www.sciencedirect.com/science/article/pii/S0753332222014810?via%3Dihub | |
dc.subject | Electrophiles | en_US |
dc.subject | Reactive aldehyde | en_US |
dc.subject | Oxidative damage | en_US |
dc.subject | Gastritis | en_US |
dc.subject | Gastric cancer | en_US |
dc.subject | DNA damage | en_US |
dc.title | The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.biopha.2022.114092 | |