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Surgical outcomes of adnexal masses classified by IOTA ultrasound simple rules

dc.contributor.authorCarballo, Erica V.
dc.contributor.authorMaturen, Katherine E.
dc.contributor.authorLi, Zhanhai
dc.contributor.authorPatel‑Lippmann, Krupa K.
dc.contributor.authorWasnik, Ashish P.
dc.contributor.authorSadowski, Elizabeth A.
dc.contributor.authorBarroilhet, Lisa M.
dc.date.accessioned2023-03-01T19:54:39Z
dc.date.available2023-03-01T19:54:39Z
dc.date.issued2022-12-17
dc.identifier.issn2045-2322
dc.identifier.otherPubMed ID36528698
dc.identifier.urihttp://hdl.handle.net/1803/18042
dc.description.abstractIOTA (International Ovarian Tumor Analysis) Simple Rules classifies adnexal masses as benign, malignant, or indeterminate based on sonographic features. We seek to determine if IOTA inappropriately directed women to surgery, or more aggressive surgery, than their final diagnosis warranted. This is a retrospective study of sonographically detected adnexal masses with known clinical outcomes from two institutions (n = 528). Surgically managed patients (n = 172) were categorized based on pathology and compared using Chi-square and t-test for categorical and continuous variables respectively. A logistic regression was used to predict characteristics that predicted surgery or imaging follow up of indeterminate masses. Of the 528 masses imaged, 29% (n = 155) underwent surgery for benign pathology. Only 1.9% (n = 10) underwent surgery after classification as malignant by IOTA for what was ultimately a benign mass. Surgical complications occurred in 10 cases (5.8%), all benign. Fifteen (3.2%) patients went into surgically induced menopause for benign masses, one of which was inaccurately classified by IOTA as malignant. Of the 41 IOTA indeterminate masses, the presence of soft tissue nodules on ultrasound was the only statistically significant predictor of the patient being triaged directly to surgery (OR 1.79, p = 0.04). Our findings support that the IOTA ultrasound classification system can provide clinical guidance without incurring unnecessary surgeries or surgical complications.en_US
dc.description.sponsorshipThe Department of Obstetrics and Gynecology at the University of Wisconsin School of Medicine and Public Health funded this project. Portions of study results have been presented at the Mid-Atlantic Gynecologic Oncology Society (MAGOS) 2019 meeting in Charlotte, NC and the Society of Gynecologic Oncology (SGO) 2020 Annual Meeting on Women's Cancer.en_US
dc.language.isoen_USen_US
dc.publisherScientific Reportsen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons. org/ licenses/ by/4. 0/. © The Author(s) 2022
dc.source.urihttps://www.nature.com/articles/s41598-022-26441-2#additional-information
dc.titleSurgical outcomes of adnexal masses classified by IOTA ultrasound simple rulesen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-022-26441-2


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