dc.contributor.author | von Beck, Kelly | |
dc.contributor.author | von Beck, Troy | |
dc.contributor.author | Ferrell Jr, P. Brent | |
dc.contributor.author | Bick, Alexander G. | |
dc.contributor.author | Kishtagari, Ashwin | |
dc.date.accessioned | 2023-02-16T21:41:05Z | |
dc.date.available | 2023-02-16T21:41:05Z | |
dc.date.issued | 2023-01-04 | |
dc.identifier.citation | von Beck, K., von Beck, T., Ferrell, P.B. et al. Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment. Blood Cancer J. 13, 5 (2023). https://doi.org/10.1038/s41408-022-00773-8 | en_US |
dc.identifier.other | PubMed ID36599826 | |
dc.identifier.uri | http://hdl.handle.net/1803/18004 | |
dc.description.abstract | Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones caused by the acquisition of somatic point mutations or mosaic chromosomal alterations (mCAs). Clonal hematopoiesis caused by somatic mutations has primarily been associated with increased risk of myeloid malignancies, while mCAs have been associated with increased risk of lymphoid malignancies. A recent study by Niroula et al. challenged this paradigm by finding a distinct subset of somatic mutations and mCAs that are associated with increased risk of lymphoid malignancy. CH driven by these mutations is termed lymphoid clonal hematopoiesis (L-CH). Unlike myeloid clonal hematopoiesis (M-CH), L-CH has the potential to originate at both stem cells and partially or fully differentiated progeny stages of maturation. In this review, we explore the definition of L-CH in the context of lymphocyte maturation and lymphoid malignancy precursor disorders, the evidence for L-CH in late-onset autoimmunity and immunodeficiency, and the development of therapy-related L-CH following chemotherapy or hematopoietic stem cell transplantation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Blood Cancer Journal | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.source.uri | https://www.nature.com/articles/s41408-022-00773-8#rightslink | |
dc.title | Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41408-022-00773-8 | |