dc.contributor.author | Werede, Ayoda T. T. | |
dc.contributor.author | Terry, James G. G | |
dc.contributor.author | Nair, Sangeeta | |
dc.contributor.author | Temu, Tecla M. M. | |
dc.contributor.author | Shepherd, Bryan E. E. | |
dc.contributor.author | Bailin, Samuel S. S. | |
dc.contributor.author | Mashayekhi, Mona | |
dc.contributor.author | Gabriel, Curtis L. L. | |
dc.contributor.author | Lima, Morgan | |
dc.contributor.author | Woodward, Beverly Owen | |
dc.contributor.author | Hannah, LaToya | |
dc.contributor.author | Mallal, Simon A. A. | |
dc.contributor.author | Beckman, Joshua A. A. | |
dc.contributor.author | Li, Jonathan Z. Z. | |
dc.contributor.author | Fajnzylber, Jesse | |
dc.contributor.author | Harrison, David G. G. | |
dc.contributor.author | Carr, John Jeffrey | |
dc.contributor.author | Koethe, John R. R. | |
dc.contributor.author | Wanjalla, Celestine N. N. | |
dc.date.accessioned | 2023-01-24T19:27:21Z | |
dc.date.available | 2023-01-24T19:27:21Z | |
dc.date.issued | 2022-12-06 | |
dc.identifier.other | eISSN 2047-9980 | |
dc.identifier.other | PubMed ID36382956 | |
dc.identifier.uri | http://hdl.handle.net/1803/17940 | |
dc.description.abstract | BackgroundPersons with HIV have a higher prevalence of coronary artery disease compared with their HIV-negative counterparts. Earlier identification of subclinical atherosclerosis may provide a greater opportunity for cardiovascular disease risk reduction. We investigated coronary cross-sectional area (CorCSA) by noncontrasted computed tomography imaging as a noninvasive measure of arterial remodeling among virally suppressed persons with HIV. Methods and ResultsWe assessed 105 persons with HIV with a spectrum of cardiometabolic health. All participants underwent computed tomography imaging to assess the mean corCSA of the proximal left anterior descending artery and 28 participants underwent additional coronary computed tomography angiography. Partial Spearman rank correlations adjusted for cardiovascular disease risk factors were used to assess relationships of corCSA with anthropometric measurements, HIV-related factors, and plasma cytokines. Mean corCSA measured by noncontrast computed tomography and coronary computed tomography angiography were strongly correlated (rho=0.91, P<0.0001). Higher mean corCSA was present in those with coronary artery calcium (P=0.005) and it correlated with participants' atherosclerotic cardiovascular disease risk score (rho=0.35, P=0.01). After adjusting for established cardiovascular disease risk factors, we observed an inverse relationship between corCSA and CD4(+) T-cell count (rho=-0.2, P=0.047). Removal of age from the model strengthened the relationships between corCSA and antiretroviral therapy duration (from rho=0.19, P=0.08 to rho=0.3, P=0.01). CorCSA was also inversely correlated with plasma IL-10 (rho=-0.25, P=0.03) but had no relationship with IL-6 (rho=0.11, P=0.4) or IL-1 beta (rho=0.08, P=0.5). ConclusionsPositive coronary arterial remodeling, an imaging marker of subclinical atherosclerosis, is associated with a lower CD4 T-cell count, lower circulating IL-10, and possibly a longer antiretroviral therapy duration in persons with HIV. RegistrationClinicaltrials.gov; Unique identifier: NCT04451980. | en_US |
dc.description.sponsorship | This work was funded by NIH grants K23 100700 (JK), R01 DK112262
(JRK and CNW), HL131977 (JB), K23 HL156759 (CNW), Doris Duke Clinical
Scientist Development Award 2021193 (CNW), Burroughs Wellcome Fund
1021480 (CNW), and the Tennessee Center for AIDS Research grant P30
AI110527 (SAM). The funding authorities had no role in study design; data
collection, analysis, or interpretation; the decision to publish; or preparation
of the manuscript. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal Of The American Heart Association | en_US |
dc.rights | © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use
is non-commercial and no modifications or adaptations are made.
JAHA is available at: www.ahajournals.org/journal/jaha | |
dc.rights.uri | https://www.ahajournals.org/doi/pdf/10.1161%2FJAHA.122.025768 | |
dc.subject | cardiovascular diseases | en_US |
dc.subject | coronary arterial calcium | en_US |
dc.subject | coronary artery disease | en_US |
dc.subject | cross-sectional area | en_US |
dc.subject | glycated hemoglobin A | en_US |
dc.subject | interleukin-10 | en_US |
dc.subject | interleukin-6 | en_US |
dc.title | Mean Coronary Cross-Sectional Area as a Measure of Arterial Remodeling Using Noncontrast CT Imaging in Persons With HIV | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1161/JAHA.122.025768 | |