dc.contributor.author | Dennis, Emily L. | |
dc.contributor.author | Humphreys, Kathryn L. | |
dc.contributor.author | King, Lucy S. | |
dc.contributor.author | Thompson, Paul M. | |
dc.contributor.author | Gotlib, Ian H. | |
dc.date.accessioned | 2020-10-22T23:27:22Z | |
dc.date.available | 2020-10-22T23:27:22Z | |
dc.date.issued | 2019-07 | |
dc.identifier.citation | Emily L Dennis, Kathryn L Humphreys, Lucy S King, Paul M Thompson, Ian H Gotlib, Irritability and brain volume in adolescents: cross-sectional and longitudinal associations, Social Cognitive and Affective Neuroscience, Volume 14, Issue 7, July 2019, Pages 687–698, https://doi.org/10.1093/scan/nsz053 | en_US |
dc.identifier.issn | 1749-5016 | |
dc.identifier.uri | http://hdl.handle.net/1803/16254 | |
dc.description.abstract | Irritability is garnering increasing attention in psychiatric research as a transdiagnostic marker of both internalizing and externalizing disorders. These disorders often emerge during adolescence, highlighting the need to examine changes in the brain and in psychological functioning during this developmental period. Adolescents were recruited for a longitudinal study examining the effects of early life stress on the development of psychopathology. The 151 adolescents (73 M/78 F, average age = 11.5 years, standard deviation = 1.1) were scanned with a T1-weighted MRI sequence and parents completed reports of adolescent irritability using the Affective Reactivity Index. Of these 151 adolescents, 94 (46 M/48 F) returned for a second session (average interval = 1.9 years, SD = 0.4). We used tensor-based morphometry to examine cross-sectional and longitudinal associations between irritability and regional brain volume. Irritability was associated with brain volume across a number of regions. More irritable individuals had larger hippocampi, insula, medial orbitofrontal cortex and cingulum/cingulate cortex and smaller putamen and internal capsule. Across the brain, more irritable individuals also had larger volume and less volume contraction in a number of areas that typically decrease in volume over the developmental period studied here, suggesting delayed maturation. These structural changes may increase adolescents vulnerability for internalizing and externalizing disorders. | en_US |
dc.description.sponsorship | Funding for this study and support for authors was provided by the National Institutes of Health (R37 MH101495, U54 EB020403, R01 AG040060, R01 NS080655, K99 NS096116 and F32 MH107129); the Brain and Behavior Research Foundation (Young Investigator Award 23819); the National Science Foundation; Klingenstein Third Generation Foundation and the Jacobs Foundation Early Career Research Fellowship (2017 1261 05). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Social Cognitive and Affective Neuroscience | en_US |
dc.rights | This article is available under the Creative Commons CC-BY-NC license and permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. | |
dc.source.uri | https://academic.oup.com/scan/article/14/7/687/5532400 | |
dc.subject | irritability | en_US |
dc.subject | brain structure | en_US |
dc.subject | tensor-based morphometry | en_US |
dc.subject | development | en_US |
dc.title | Irritability and brain volume in adolescents: cross-sectional and longitudinal associations | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1093/scan/nsz053 | |