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Surgical guidance of soft tissue sarcoma excision using near-infrared Raman spectroscopy and autofluorescence imaging
(2018-01-26)
Soft tissue sarcomas (STS) are a rare and heterogeneous form of malignant tumors that arise from mesenchymal progenitors and are primarily treated through surgical resection and radiation. A positive surgical margin is the ...
Physical Basis of Acousto-Optical Imaging
(2014-11-25)
Acousto-Optical Imaging (AOI) is an emerging hybrid multi-modal imaging technique that combines the high spatial resolution of ultrasound with the versatile molecular sensitivity of optical detection to improve upon the ...
Direct analysis of endogenous and exogenous compounds in whole-animal tissue sections by imaging MALDI mass spectrometry
(2007-12-27)
In recent years, technological advances have improved our understanding of disease and infection at the molecular level. Genomic and proteomic studies have identified a large number of potential therapeutic targets for ...
Imaging and Genetics of Two Amyloid Related Diseases: Alzheimer’s Disease and Down Syndrome
(2014-02-20)
Alzheimer’s Disease is an irreversible, degenerative disease of the brain that accounts for a majority of dementia cases each year, in both the general population and in patients with Down Syndrome. The advancement of in ...
High-throughput analysis of tissue microarrays of disease: combining in situ proteomics with MALDI imaging mass spectrometry
(2009-08-04)
Biological systems are extremely complex and new tools are necessary to effectively enhance our knowledge and understanding of their underlying mechanisms. Mass spectrometry has proven to be an essential technology for ...
Proteomic analysis and classification of metastatic melanoma by MALDI imaging mass spectrometry
(2011-01-12)
CHEMISTRY
PROTEOMIC ANALYSIS AND CLASSIFICATION OF METASTATIC MELANOMA BY MALDI IMAGING MASS SPECTROMETRY
WILLIAM MICHAEL HARDESTY
Dissertation under the direction of Professor Richard M. Caprioli
Classification of ...
Development of Photothermal Optical Coherence Tomography for In Vivo Imaging of Contrast Agents
(2015-07-28)
Sensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight into mechanisms of disease formation ...
Development and Characterization of Novel Bioluminescent Reporters of Cellular Activity
(2019-04-08)
Over the years, periodic innovations in fluorescence microscopic technologies have afforded researchers a more sophisticated understanding of the inner workings of the cell. These methods are valuable but drawbacks include ...
Investigation of the Effect of Tissue Water Dynamics on Compartmental MRI Measurements using Contrast Enhanced Relaxometry and SPECT
(2012-04-11)
Magnetic resonance imaging (MRI) provides methods for characterizing tissue micro-structure using relaxation-based measurements with and without the use of contrast agents (CA). Two techniques, dynamic contrast enhanced ...
FLT PET in colorectal cancer
(2013-04-15)
Biomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. With an increasing reliance on molecularly targeted therapies, there remains an equally critical challenge ...