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Exploring Predictors of Affective State during d-Amphetamine Intake
(Vanderbilt University, 2019-04-08)
Dopamine sensing with carbon nanotubes and graphite electrodes
(2011-08-08)
The superior material properties of carbon nanotubes (CNTs) such as high aspect ratio, high surface area, superb mechanical properties, thermal and chemical stability have generated enormous research activities to push for ...
From the Gut to the Brain: Hormonal Regulation of Brain Dopamine Homeostasis and Cocaine Reward
(2016-07-27)
Addiction is a disorder characterized by drug use despite negative consequences. Drugs of abuse hijack circuits within brain centers which evolved to respond to natural rewards such as palatable, calorie-dense foods. This ...
The role of insulin and Akt in the regulation of the norepinephrine transporter and monoamine homeostasis
(2010-07-15)
Monoamine signaling in the central nervous system plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for autonomic function in the peripheral nervous ...
Studies of the Physiological Function of the Melanocortin 3 Receptor
(2014-06-23)
The central melanocortin receptors have classically been implicated in the maintenance of energy homeostasis, though their expression in hypothalamus and brainstem. Two melanocortin receptors are predominantly expressed ...
The Role of Insulin Signaling on Dopamine Transporter Trafficking
(2010-08-04)
Dopaminergic neurotransmission is a critical component in the regulation of several behaviors, including cognition, motor function, motivation, and reward. Abnormalities in dopamine (DA) signaling have been linked to ...
Reverse Transport of the Dopamine Transporter in Neuropsychiatric Disease: Mechanisms of Regulation and Dysfunction
(2017-02-22)
The dopamine (DA) transporter (DAT) is a presynaptic membrane protein that regulates dopaminergic neurotransmission by controlling DA levels at the synapse via active reuptake. The DAT is also capable of engaging in reverse ...
Characterization of genetically labeled dopamine neurons and circadian studies of the zebrafish retina
(2008-03-13)
Dopamine plays key roles in many basic functions in the central nervous system. In order to study developmental and functional roles of dopaminergic cells in the zebrafish, we have examined a transgenic line of zebrafish ...
Identification and characterization of a novel, conserved metallo-β-lactamase regulator of dopamine and glutamate signaling
(2013-09-13)
Coordinated neurotransmission of fast acting neurotransmitters like glutamate (GLU) and neuromodulators such as dopamine (DA) is critical for the proper execution of complex behaviors such as cognition, locomotor control, ...
Prefrontal and Striatal Catecholamine Dysfunction in the Neuronal Rictor Null
(2013-12-03)
Disruption in insulin signaling is a mechanism hypothesized to underlie many neurologic and psychiatric disorders. Insulin signaling is accomplished by a complex array of intracellular effectors, including the protein ...