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Behavioral Genetics and Crime, In Context
(Law and Contemporary Problems, 2006)
This Article provides an introduction to some of the key issues at the intersection of behavioral genetics and crime.
It provides, among other things, an overview of the emerging points of consensus, scientifically, on ...
Is it Time for a Universal Genetic Forensic Database?
(Science, 2018)
There is evidence that existing forensic databases have more than made up for their initial costs by increasing the efficiency, accuracy, and success rate of ongoing criminal investigations and by deterring would-be crimals. ...
Probing the Cellular Uptake of DNA Functionalized Gold Nanoparticles
(2017-07-31)
Gold nanoparticles conjugated to short sensing strands of DNA have been successfully applied to therapeutic silencing and intracellular detection of disease-associated mRNAs. These biomedical applications are possible ...
The Design and Characterization of DNA-Based Viral Diagnostics
(2010-09-06)
Early detection of pediatric viruses is critical to effective intervention. A successful clinical tool must have a low detection limit, be simple to use and report results quickly. This work describes the integration of ...
Role of DNA interactions in modulating the activity of human topoisomerases and anticancer drugs
(2011-03-18)
Human topoisomerase I and topoisomerase IIα and IIβ play critical roles in regulating the topological state of DNA and are targets for some of the most widely prescribed anticancer drugs currently in clinical use. These ...
DNA Lesions as Cellular Poisons of Topoisomerase II-alpha
(2005-11-02)
Topoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...
Strategies to Improve Malaria Diagnostics at the Point of Care by Understanding Protein Behavior and Developing Low-Resource DNA Detection Methods
(2017-03-31)
Point-of-care diagnostics for malaria currently rely on antibody-based rapid diagnostic tests (RDTs), but these tests are in danger of becoming obsolete as the world moves to eliminate malaria. More sensitive and robust ...
Characterization of the 2,6-Diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA Lesion
(2018-11-27)
Alkylating agents, once a weapon of war employed in World War I, are the oldest class of chemotherapeutic agents still used today, with applications in treating a wide array of cancers. Methylating agents, in particular, ...
Molecular dynamics simulation of a nanoscale device for fast sequencing of DNA.
(2007-12-13)
We report a molecular-simulation based modeling of transport and orientation properties of single-stranded DNA molecules in a nanoscale channel as a part of a larger nanoscale device designed for rapid DNA sequencing. The ...
Optimization of a pulsed source-sink micromixing device
(2004-12-07)
The optimization of a pulsed source-sink micromixing device (PSSMD) is presented in this thesis. In particular the behavior of pulsed source-sink pairs activated to produce mixing in a thin rectangular chamber is ...