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Targeting Lipid Dicarbonyls to Prevent Inflammation-mediated Atrial Fibrillation
(2023-06-05)
Inflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
Cytokine-induced Extracellular Matrix Alterations in Diabetic Retinopathy Pathogenesis
(2021-11-19)
Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans. Chronic low-grade retinal inflammation is an essential contributor to the pathogenesis of DR, as it is known to drive many of the ...
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis
(Open Forum Infectiouis Diseases, 2019-12)
Background. Community-acquired pneumonia (CAP) is the leading cause of death in children. Identification of reliable bio-markers offers the potential to develop a severity quantitative score to assist in clinical decision-making ...
Targeting Lipid Dicarbonyls to Prevent Inflammation-mediated Atrial Fibrillation
(2023-06-05)
Inflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
Effects of Interleukin-1 beta Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk A Secondary Analysis of CANTOS
(Hypertension, 2020-02)
While hypertension and inflammation are physiologically inter-related, the effect of therapies that specifically target inflammation on blood pressure is uncertain. The recent CANTOS (Canakinumab Anti-inflammatory Thrombosis ...