Browsing by Subject "fibrosis"
Now showing items 1-5 of 5
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(2022-03-15)Department: Biomedical EngineeringIn 2017 the sclerostin targeting monoclonal antibody Romosozumab was approved as a treatment for post-menopausal osteoporosis (PMO) despite cardiovascular side effects discovered in clinical trials. Previous studies indicated ...
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(2015-12-04)Department: Cell and Developmental BiologyMyocardial infarction (MI) causes irreversible tissue damage, leading to heart failure. Our laboratory found canonical Wnt signaling and the Wnt10b ligand are strongly induced in mouse and human hearts after MI. Wnt10b ...
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(NATURE COMMUNICATIONS, 2019-07-09)Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a ...
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(2022-01-13)Department: Biomedical EngineeringCardiac fibroblasts are activated during injury, where they become the cells tasked with depositing and compacting collagen leading to interstitial fibrosis. Overactivity of cardiac fibroblasts leads to extensive stiffening ...
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(2015-06-05)Department: Cell and Developmental BiologyRetinoic acid (RA) has been used therapeutically to reduce injury and fibrosis in models of acute kidney injury (AKI), but little is known about whether and how this pathway is normally regulated, and what role it plays ...