Browsing by Subject "epilepsy, mTOR, iPSC, DEPDC5, GATOR1"
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(2020-07-06)Department: NeuroscienceMutations in the DEPDC5 gene cause focal epilepsies. DEPDC5 encodes an essential component of the GATOR1 complex, a negative regulator of the mTORC1 pathway. Dysregulation of mTORC1 signaling due to DEPDC5 mutation likely ...