Browsing by Subject "enhancer"
Now showing items 1-4 of 4
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(2017-05-26)Department: Human GeneticsLung cancer is classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC has several subtypes, but the two most commonly occurring subtypes are lung adenocarcinoma (LUAD) ...
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Mechanism of Transcriptional control of oncogenic transcription factor fusions in tumor development (2022-06-16)Department: BiochemistryGene expression networks are perturbed in every human malignancy. One common way that this occurs is through chromosomal translocation, such as t(8;21) or t(2;13), which fuse parts of two transcription factors to create a ...
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(2024-02-28)Department: BiochemistryTranscription is dysregulated in the majority of human cancers. Understanding how normal transcriptional programs are dysregulated in cancers is crucial to understanding how cancers develop and successfully treating them. ...
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(2019-11-15)Department: Biological SciencesEnhancers are genomic regions distal to promoters that bind transcription factors (TFs) to regulate the dynamic spatiotemporal patterns of gene expression required for proper differentiation and development of multi-cellular ...