Browsing by Subject "drug discovery"
Now showing items 1-9 of 9
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(2016-11-18)Department: ChemistryLigand-based computational drug discovery (LB-CADD) methods have been used widely over the last several decades to aid medicinal chemistry campaigns via virtual high-throughput screening (vHTS) and de-novo molecular design. ...
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Discovery and characterization of G protein-gated, inwardly-rectifying, potassium channel modulators (2018-10-16)Department: PharmacologyG protein-gated, inwardly-rectifying, potassium (K+) (GIRK) channels are important regulators of cellular excitability throughout the body. GIRK channels are composed of four subunits and exist as homomeric and heteromeric ...
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(2013-03-01)Department: ChemistryThe most common approaches to treatment of cancer are chemo- and radiation-therapies that cause DNA damage. The efficiency of these treatments is reduced over time because cells up-regulate DNA damage response and repair. ...
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(2013-02-26)Department: ChemistryThe emergence of drug resistant strains of Plasmodium spp. creates a critical need for the development of novel antimalarials. Hemozoin, a crystalline heme detoxification biomineral vital to parasite survival, serves as ...
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(2013-07-29)Department: ChemistryMalaria is a disease caused by the parasite Plasmodium falciparum which kills 1-2.7 million people per year. Parasite resistance to widely available anti-malarial treatments such as Chloriquine is spreading rapidly, and ...
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(2014-05-28)Department: PharmacologyInward rectifier potassium (Kir) channels are a family of two transmembrane-spanning potassium selective ion channels. Kir channels are found in all kingdoms of life where they play essential roles in regulating numerous ...
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(2012-11-21)Department: PharmacologyProstaglandin E2 (PGE2) is a lipid autacoid, which is an oxidative metabolite of arachidonic acid synthesized by cyclooxygenase and prostaglandin E synthases. PGE2 is proposed to mediate in part the pathophysiology of ...
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(2015-11-24)Department: PharmacologyMalignant cancers are the second leading cause of death in the United States, with a projected 1.6 million new diagnoses per year and almost 600,000 deaths. Our understanding of the molecular pathways causing tumor initiation, ...
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(2021-02-10)Department: Cell & Developmental BiologyWDR5 is a conserved WD40-repeat protein that rose to prominence through its role in epigenetic complexes, including the KMT2 (MLL/SET) enzymes that deposit histone H3 lysine 4 methylation and the non-specific lethal complex ...