Browsing by Subject "drug delivery"
Now showing items 1-20 of 20
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A Piezoelectric Ink Jet Printing Platform to Engineer Microparticles for Drug Delivery Applications (2018-07-18)Department: Chemical EngineeringMicroparticles are widely researched for use as drug delivery vehicles for numerous applications due to their ability to eliminate side effects and decrease dose frequency. However, there lacks a comprehensive technology ...
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(2019-03-25)Department: Chemical EngineeringMetastasis is the major prognostic factor for cancer patient survival, and breast tumors have a striking propensity for metastasis to bone. Once tumors establish in bone, they initiate what is colloquially known as the ...
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(2021-10-13)Department: Biomedical EngineeringHelper T cell activity is dysregulated in a number of diseases with limited treatment options, including those associated with rheumatic autoimmunity. Phosphodiesterase 4 (PDE4) inhibition has the potential to enable ...
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(2018-11-15)Department: Biomedical EngineeringAdvanced organic chemistry allows for design of unique nanocarriers that have specific functions tailored for in vivo applications, such as decorating with mannose to target tumor-associated macrophages for immunotherapy ...
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(2021-11-18)Department: Biomedical EngineeringCell-based therapies are becoming an increasingly popular strategy for treating a multitude of pathologies, especially those characterized by loss of or atypical cellular function. However, acute and chronic immune rejection ...
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(2019-02-18)Department: ChemistryPolymers possess many properties which make them ideal for drug delivery platforms, yet both the development and manufacturing creates challenges toward the material advancement. By governing the functionality of polymers ...
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(2018-11-16)Department: Biomedical EngineeringT cell activity is dysregulated in a number of autoimmune diseases for which systemic lupus erythematosus is a prime example. Treatment options are limited and usually consist of overt immune suppression and compromised ...
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(2022-05-16)Department: Biomedical EngineeringTriple negative breast cancer (TNBC) is characterized by a lack of estrogen receptor, progesterone receptor, and HER2. Patients with TNBC therefore cannot benefit from treatment with one of the molecularly targeted therapies ...
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(2015-04-05)Department: Biomedical EngineeringPeptide-based therapeutics hold significant therapeutic potential for use in a variety of clinical applications ranging from cancer to cardiovascular disease. However, the potential of peptide-based therapeutics is limited ...
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(2014-04-15)Department: Chemical EngineeringOverall cancer fatalities have stabilized since the early 1990s, however the prevalence of cancer is still remarkably high for men (45%) and women (38%). While the recent advances in treatments for cancers have increased ...
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(2014-12-03)Department: Chemical and Physical BiologyCurrent chemotherapeutic treatments for cancer utilize systemic administration of cytotoxic drugs and produce many side effects in healthy tissues, making optimal treatment of cancer hard to achieve. Tumor targeted ...
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(2017-03-31)Department: Interdisciplinary Materials ScienceResearchers discovered the existence of non-coding RNA while unraveling the secrets of the human genome. Non-coding RNA molecules are never translated into proteins, yet they are highly abundant and serve critical functions ...
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(2016-11-21)Department: Biomedical EngineeringAlthough siRNA-based therapeutics hold great promise for systemic cancer treatment, polyplex nanocarrier systems face many intravenous challenges that limit their pharmacokinetic potential and therefore reduce tumor ...
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(2014-11-26)Department: Interdisciplinary Materials ScienceCancer, a diagnosis that encompasses over 200 different disease states classified as malignant neoplasms, is poised to become the leading cause of death in the United States. Many of these diseases arise in the form of ...
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(2022-07-18)Department: Biomedical EngineeringLong-term, sustained drug release utilizing an injectable delivery vehicle in localized, chronic diseases is a therapeutic strategy with the potential to extend the action of drugs, reduce drug off-target side effects, and ...
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(2014-06-11)Department: PharmacologyPHARMACOLOGY Nanonetworks as Innovative Platforms for Therapeutic Solubilization and Delivery David Michael Stevens Dissertation under the direction of Professor Eva M. Harth Solubility remains the biggest obstacle in ...
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(2008-05-14)Department: Biomedical EngineeringBIOMEDICAL ENGINEERING NANOSCALE SURFACE ENGINEERING FOR BIOIMAGING AND DRUG DELIVERY ASHWATH JAYAGOPAL Dissertation under the direction of Professor Frederick R. Haselton Nanoengineering of device interfaces permits ...
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(2019-07-23)Department: Biomedical EngineeringSince the FDA approved the first recombinant protein 37 years ago, drug developers have harnessed biologics to treat human disease. Despite tremendous progress in extracellular biologic development, there are only eight ...
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(2006-11-20)Department: Chemical EngineeringThis study focused on creating water-based, targeted, nanoparticulate polyelectrolyte complex (PEC) drug delivery vehicles. The polymeric structure of PECs allowed for integration of an anti-angiogenic, heparin binding ...
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(2015-12-04)Department: ChemistryThe polymerization of glycidol has been studied for some time due to the numerous uses for the product polymer species, including the transportation of drug molecules and biological cargo, biomineralization, and even solid ...