Browsing by Subject "T cell"
Now showing items 1-8 of 8
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(2023-06-22)Department: Molecular Pathology & ImmunologyWomen have higher rates of severe asthma compared to men. Severe asthma is characterized by increased Th2-mediated eosinophils and/or Th17-mediated neutrophils in the airway, leading to increased airway hyperresponsiveness ...
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(2011-04-29)Department: Microbiology and ImmunologyHIV-epitope-specific T cell responses are critical components of the natural immune response to HIV infection, but these cells often become dysfunctional in chronic infection. Structural diversity within the epitope-specific ...
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(2019-06-27)Department: Microbiology and ImmunologyRecent advances in computational biology and sequencing technologies have led to the development of assays that generate a large number of measurements on a large number of samples (individuals or single cells). Experimental ...
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(2015-03-26)Department: Microbiology and ImmunologyMy thesis project explores mechanisms of innate immune evasion by human metapneumovirus (HMPV), as well as the consequences of a lack of type I IFN (IFNAR) signaling on host response and pathogenesis. I show that the ...
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(Frontiers in Immunology, 2019-09-25)Our previous studies of protective immunity and pathology against blood stage malaria parasites have shown that not only CD4(+) T cells, but also CD8(+) T cells and macrophages, are important for host defense against blood ...
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(Arthritis Research & Therapy, 2019-06-25)BackgroundGATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. ...
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(Arthritis Research & Therapy, 2019-06-25)BackgroundGATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. ...
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(2009-03-28)Department: Microbiology and ImmunologyCD8+ T cells are a critical component of an HIV-specific immune response. Our studies aimed to define the T cell receptor (TCR) structural determinants as well as effector functions associated with CD8+ T cell suppression ...