Browsing by Subject "P-TEFB"

Now showing items 1-2 of 2

    • The CDK7 Inhibitor THZ1 Alters RNA Polymerase Dynamics at the 5 ' and 3 ' Ends of Genes 
      Sampathi, Shilpa; Acharya, Pankaj; Zhao, Yue; Wang, Jing; Stengel, Kristy; Liu, Qi; Savona, Michael R.; Hiebert, Scott W. (NUCLEIC ACIDS RESEARCH, 2019-05)
      The t(8;21) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). We found that t(8; 21) AML were extremely sensitive to THZ1, which triggered apoptosis after only 4 h. We ...
    • lBromodomain inhibitor JQ1 reversibly blocks IFN-gamma production 
      Gibbons, Hunter R.; Mi, Deborah J.; Farley, Virginia M.; Esmond, Tashawna; Kaood, Mary B.; Aune, Thomas M. (Scientific Reports, 2019-07-16)
      As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...