Browsing by Subject "Alzheimer's disease"
Now showing items 1-9 of 9
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(DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA, 2018)Background/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. ...
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(Journal of the American Heart Association, 2019-08-06)Background-Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-epsilon 4 is a genetic susceptibility ...
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(2009-08-11)Department: NeuroscienceDissertation under the direction of Professor Edwin J. WEeber Apolipoprotein E (apoE) interacts with lipoprotein receptors in the hippocampus. These receptors are intimately involved in the modulation of synaptic plasticity, ...
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(2022-06-13)Department: BiochemistryAlzheimer’s disease (AD) is the most common form of dementia in the U.S. with no disease-modifying therapies. A key hallmark of AD is the generation of amyloid-β (Aβ) peptides and plaques, which have long been thought to ...
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(2020-06-14)Department: PharmacologyNo current pharmacologic treatments stop the progression of Alzheimer’s disease (AD), the most common major neurocognitive disorder. High levels of cerebrospinal fluid (CSF) vascular endothelial growth factor (VEGFA) are ...
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(Vanderbilt News Service, 2006-03-16)
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(2010-04-15)Department: PharmacologyMuscarinic acetylcholine receptors (mAChRs), specifically M1 and M4 subtypes, provide viable targets for the treatment of multiple central nervous system disorders. However, highly selective activators of either M1 or M4 ...
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(2022-03-27)Department: NeuroscienceParvalbumin interneurons (PV-INs), a subset of inhibitory interneurons, are defined by their fast-spiking phenotype and by the presence of the calcium-binding protein parvalbumin. PV-INs are vulnerable to many stressors, ...
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(Vanderbilt University, 2015-12)Current literature on the effects of sleep on cognition has shown conflicting results regarding the effects of long and short sleep duration. Using previously collected data from the Vanderbilt Memory & Aging Project, this ...