Browsing by Department "Pharmacology"
Now showing items 1-20 of 140
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(2011-11-23)Department: PharmacologyMercury accumulates in fish-eating populations. Glial cells have diverse functions including providing nutrition[1], maintaining CNS homeostasis, removing pathogens, inducing neuronal differentiation and mediating CNS ...
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(2022-03-29)Department: PharmacologyThyroid cancer incidence is rapidly increasing in the United States, with over 45,000 patients projected to be diagnosed in 2022. While the vast majority of patients respond well to first line treatment, approximately 20% ...
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(2016-11-28)Department: PharmacologyUnacceptable pharmacokinetics (PK) relating to aldehyde oxidase (AO) metabolism have resulted in clinical failure of several promising drug candidates, yet reliable and standardized methods to predict the human PK and ...
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(2013-12-16)Department: PharmacologyMetabotropic glutamate receptors (mGlus) are a group of Family C Seven Transmembrane Spanning Receptors that play important roles in modulating signaling transduction, particularly within the central nervous system. mGlu4 ...
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An ensemble recruited by α2a-adrenergic receptors is engaged in a stressor-specific manner in mice (2022-11-14)Department: Pharmacologyα2a-adrenergic receptor (α2a-AR) agonists are candidate substance use disorder therapeutics due to their ability to recruit noradrenergic autoreceptors to dampen stress system engagement. However, we recently found that ...
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(2012-06-22)Department: PharmacologyArrestins bind G protein-coupled receptors and more than 100 non-receptor partners, regulating various signaling pathways and cellular functions. The interactions of many proteins (e.g., Src, JNK3, ERK½, Mdm2, etc.) with ...
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(2019-03-11)Department: PharmacologyThe four vertebrate arrestins comprise a family of proteins that are responsible for the desensitization and internalization of over 800 subtypes of G protein-coupled receptors (GPCRs). The arrestins also serve as independent ...
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(2005-12-16)Department: PharmacologyADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-selective conversion of adenosine to inosine. Previous studies from our laboratory have demonstrated that ...
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(2015-01-16)Department: PharmacologyPhospholipase D (PLD) is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms that generates phosphatidic acid. A number of human bacterial pathogens produce PLD as virulence factors to promote infections. ...
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(2013-09-19)Department: PharmacologyBiosynthesis of lipid mediators including the leukotrienes, lipoxins, eoxins, resolvins, and protectins entails the lipoxygenase (LOX) catalyzed synthesis of an allylic epoxide intermediate, designated as leukotriene A4 ...
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(2017-04-05)Department: PharmacologyHeart development depends on coordinated proliferation and differentiation of cardiac progenitor cells, but how the two processes are synchronized is not well understood. The data herein show that the secreted BMP antagonist ...
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(2009-12-01)Department: PharmacologyPHARMACOLOGY Ca2+-SELECTIVE TRPM CHANNELS REGULATE IP3-DEPENDENT Ca2+ OSCILLATIONS IN THE C. ELEGANS INTESTINE Juan Xing Dissertation under the direction of Professor Kevin Strange Posterior body wall muscle contraction ...
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(2010-01-18)Department: PharmacologyMethylmercury (MeHg), a known neurotoxicant, is found in seafood, leading to regular exposure of humans to this compound. Many of the molecular targets and detoxifying components of MeHg toxicity, including glutathione ...
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(2010-04-12)Department: PharmacologyAcetylcholine (ACh) was one of the first neurotransmitters discovered and has been implicated in regulating a number of physiologic processes within the CNS and the periphery. Cholinergically-mediated physiology requires ...
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(2011-10-19)Department: PharmacologyHuman subjects with impaired baroreflex function cannot buffer rises or falls in blood pressure (BP), thus allowing BP effects of endogenous or environmental stimuli that previously escaped detection to emerge dramatically. ...
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(2011-02-21)Department: PharmacologyComplex II superfamily members catalyze two separate reactions in respiration: interconversion of fumarate and succinate in the soluble milieu and interconversion of quinol and quinone in the membrane. Electrons liberated ...
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(2023-01-11)Department: PharmacologyThe study of endogenous and phyto- cannabinoids share a rich and intertwined history, with the discovery of the endogenous cannabinoid (eCB) system occurring serendipitously during efforts to elucidate the biological ...
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(2019-09-17)Department: PharmacologyThe sympathetic nervous system is a major efferent pathway through which the central nervous system controls peripheral organ function. Genetic and pharmacologic evidence in mice indicated that stimulation of the β2 ...
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(2012-04-26)Department: PharmacologyProteostasis is maintained by a complex network of genes and processes which includes core synthesis and degradation machineries as well as chemical and protein chaperones. Much of what is known about the function and ...
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(2008-07-17)Department: PharmacologyInvestigating genetic forms of epilepsy allows for improved understanding of epilepsy pathophysiology in general. Mutations in voltage-gated sodium channels are a frequent cause of genetic forms of epilepsy. First we ...