Browsing by Author "Zanic, Marija"

Now showing items 1-8 of 8

    • Dynamics and Regulation of Microtubule Minus Ends 
      Strothman, Claire E; 0000-0001-7849-0626 (2021-06-08)
      Department: Cell & Developmental Biology
      Dynamics and Regulation of Microtubule Minus Ends Microtubules are an integral part of the cytoskeletal system in cells and serve essential roles in cell division, intracellular transport, and morphogenesis. Microtubules ...
    • Investigating the molecular mechanisms of microtubule catastrophe 
      Farmer, Veronica Jeanne; 0000-0003-3857-5793 (2022-03-29)
      Department: Cell & Developmental Biology
      The microtubule network in cells continuously remodels to facilitate its vital functions in cell division, cell motility and intracellular transport. Organization of the microtubule network is enabled by regulation of the ...
    • Investigating the role of CLASPs in microtubule and actin filament interactions 
      Rodgers, Nikki Christina; 0000-0003-2711-9581 (2023-03-14)
      Department: Chemical & Physical Biology
      Microtubules and actin filaments coordinate to remodel the cytoskeleton to facilitate proper cell migration. The coordination between microtubules and actin filaments are regulated by 1) chemical signals and 2) physical ...
    • Microtubule minus-end stability is dictated by the tubulin off-rate 
      Strothman, Claire; Farmer, Veronica; Arpag, Goker; Rodgers, Nicole; Podolski, Marija; Norris, Stephen; Ohi, Ryoma; Zanic, Marija (Journal of Cell Biology, 2019-09)
      Dynamic organization of microtubule minus ends is vital for the formation and maintenance of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases of assembly and disassembly, a behavior ...
    • Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends 
      Reid, Taylor A.; Coombes, Courtney; Mukherjee, Soumya; Goldblum, Rebecca R.; White, Kyle; Parmar, Sneha; McClellan, Mark; Zanic, Marija; Courtemanche, Naomi; Gardner, Melissa K. (eLIFE, 2019-09-03)
      The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 ...
    • The ClpP peptidase grips a model protein substrate against external force 
      Walker, Steven Dee; 0000-0002-1203-9717 (2022-11-15)
      Department: Chemical & Physical Biology
      ATPases Associated with diverse cellular Activities (AAA+) proteases power the maintenance of protein homeostasis by coupling ATP hydrolysis to mechanical protein unfolding, translocation, and ultimately degradation. Though ...
    • The ClpP peptidase grips a model protein substrate against external force 
      Walker, Steven Dee; 0000-0002-1203-9717 (2022-11-15)
      Department: Chemical & Physical Biology
      ATPases Associated with diverse cellular Activities (AAA+) proteases power the maintenance of protein homeostasis by coupling ATP hydrolysis to mechanical protein unfolding, translocation, and ultimately degradation. Though ...
    • The Design and Fabrication of a Two-Layer Microfluidic Device for Studying Microtubules In Vitro 
      Rogers, Matthew Robert; 0000-0003-4691-5778 (2022-03-28)
      Department: Chemical Engineering
      Here, we detail the design and fabrication of a two-layer microfluidic device to be used to investigate microtubule dynamics and mechanics in vitro. The design basis was precipitated by our desire to utilize the intrinsic ...