Browsing by Author "P. Anthony Weil"
Now showing items 1-11 of 11
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Umunakwe, Obinna C. (2014-08-04)Department: PathologyCystic fibrosis (CF) is a debilitating, multi-organ, autosomal recessive disease caused by mutations leading to absence of functional cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial cells. Chronic ...
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Woodward, Emily Jean (2006-10-09)Department: Microbiology and ImmunologySelf-reactive B lymphocytes are frequently produced as a consequence of B cell antigen receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by tolerance mechanisms survive and mature in the ...
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Walheim, Danielle Marie (2016-03-11)Department: Molecular Physiology and BiophysicsEvidence suggests that chromatin-modifying complexes contribute to the uncontrolled cell proliferation of cancer cells through dysregulation of the epigenome. Histone deacetylases (HDACs) are a type of chromatin modifying ...
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Zhou, Zheng (2006-04-06)Department: Molecular Physiology and BiophysicsThe protein complex composed of the cytoplasmic domain of band 3 (cdb3) and ankyrin forms one of the two major contact sites between the spectrin-based membrane skeleton and the lipid bilayer in human erythrocytes. This ...
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Browne, Christopher Michael (2013-06-04)Department: BiochemistryThis dissertation focuses on the biochemical and genetic characterization of the protein-protein interaction in the budding yeast Saccharomyces cerevisiae between the cytosolic translation initiation guanine nucleotide ...
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Bersell, Kevin Richard (2016-11-03)Department: PharmacologyThe application of genome science to inherited heart disease requires accurate genetic evaluation and understanding of physiologic resulting from genetic variation. Using a Long QT syndrome phenotype that is very suggestive ...
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Mitchell, Sabrina L. (2010-12-07)Department: Human GeneticsNeither genome size nor gene number is indicative of organism complexity. Complex regulation of genes within a genome likely contributes to organism complexity. Coordinate regulation of genes through shared cis regulatory ...
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Meyer, Amanda N. (2017-06-01)Department: Molecular Physiology and BiophysicsThe enhancer DNA-binding transfactor Repressor activator protein 1 (Rap1) performs several essential cellular functions in the budding yeast Saccharomyces cerevisiae. These functions include regulation of telomere length, ...
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Garcia, Christina Valerie Boma (2011-09-26)Department: Cancer BiologySynovial sarcoma (SS) is a rare but aggressive malignancy that is typically diagnosed in adolescents and young adults. These tumors are characterized by the presence of a specific chromosomal translocation t(X;18)(p11.2;q11.2) ...
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Lamar, Clifford Ragsdale (2007-12-28)Department: Molecular Physiology and BiophysicsThe melanocortin 4 receptor (MC4R) is a G-protein coupled receptor, which is widely, yet weakly, expressed throughout the CNS. Although the sites of MC4R expression are known, the field still does not understand how the ...
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Howard, Gregory Caleb (2016-08-31)Department: Cell and Developmental BiologyThe ubiquitin–proteasome system (UPS) influences gene transcription in multiple ways. One way in which the UPS impacts transcription centers on transcriptional activators, the function of which can be stimulated by components ...