Browsing by Author "Ian Macara"

Now showing items 1-10 of 10

    • Dissecting Complex Mechanisms of Calcium Influx in a Simple Wound System 
      Shannon, Erica Kristine (2017-09-14)
      Department: Cell and Developmental Biology
      In normal epithelial wound repair, cells across an epithelial sheet begin a coordinated process of re-epithelialization within minutes of wounding. These coordinated behaviors are driven by a calcium wave, a rise in ...
    • F-BAR protein function in cytokinesis: studies of phosphoregulation and disordered domains 
      Mangione, MariaSanta (2019-09-13)
      Department: Cell and Developmental Biology
      Cytokinesis is the physical separation of two daughter cells. Coordination of cytokinesis with genome duplication and segregation is essential for the viability of all cells. Yeast, amoebas, and animal cells assemble an ...
    • Identification of a role for integrin alpha 5 in colonic epithelial morphogenesis 
      Starchenko, Alina (2017-04-04)
      Department: Cell and Developmental Biology
      Apico-basolateral polarity is a fundamental property of epithelial cells, and its loss is a hallmark of colorectal cancer (CRC). Role(s) for lateral integrins in this polarization process and the consequences of their ...
    • Lkb1 controls expansion and folding of the cerebellar cortex 
      Ryan, Kaitlyn Elizabeth (2014-11-26)
      Department: Cell and Developmental Biology
      Cerebellar growth and foliation require the Hedgehog-driven proliferation of granule cell precursors (GCPs) in the external granule layer (EGL). However, that increased or extended GCP proliferation generally does not ...
    • Nanoscale architecture of F-BAR proteins and the Schizosaccharomyces pombe contractile ring 
      McDonald, Nathan Andrew (2017-07-13)
      Department: Cell and Developmental Biology
      Cytokinesis is the final step in the cell cycle where one cell is physically divided into two. Animal and fungal cells perform cytokinesis with an actin- and myosin-based molecular machine, the contractile ring. A complete ...
    • Regulation of WNT pathway specification by DUB-E3 interactions 
      Nielsen, Casey Paulasue (2019-09-09)
      Department: Cell and Developmental Biology
      The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...
    • RSKy Business in the Mammary Gland 
      Ludwik, Katarzyna Anna (2018-04-11)
      Department: Pathology
      The family of ribosomal S6 Ser/Thr protein kinases (RSK) controls proliferation, viability and motility and, therefore, contributes to the etiology of numerous cancers, including breast. We found that RSK2 is an obligate ...
    • SAN1 - a novel nuclease involved in interstrand cross-link repair 
      Andrews, Alex Michael (2018-07-11)
      Department: Cell and Developmental Biology
      The DNA damage response consists of complex signaling pathways that act to recognize and remove various types of genomic insults. One particularly dangerous type of lesion is an interstrand cross-link (ICL). ICLs are ...
    • Targeting the Ser/Thr protein kinase RSK to reduce breast cancer metastasis 
      Mrozowski, Roman Michal (2015-07-21)
      Department: Pathology
      RSK is a family of four Ser/Thr protein kinases activated by ERK1/2 signaling. RSK is often misregulated in a variety of cancers, including breast and prostate. More recently, RSK1 and RSK2 have been shown to promote ...
    • Tumor suppressor mechanisms of the polarity protein Par3 
      Guyer, Richard Allen (2015-07-17)
      Department: Cell and Developmental Biology
      Proteins that regulate cell polarity are fundamental for metazoan biology and are necessary for proper development of tissues and organs. In light of polarity genes’ fundamental role in tissue organization, disruptions ...