Browsing by Author "Farley, Virginia M."

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    • lBromodomain inhibitor JQ1 reversibly blocks IFN-gamma production 
      Gibbons, Hunter R.; Mi, Deborah J.; Farley, Virginia M.; Esmond, Tashawna; Kaood, Mary B.; Aune, Thomas M. (Scientific Reports, 2019-07-16)
      As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...