Browsing by Author "David L. Tabb"
Now showing items 1-8 of 8
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Templeton, Neil Andrew (2014-11-25)Department: Chemical EngineeringWe have applied 13C metabolic flux analysis (13C MFA) to develop a system-wide understanding of the central carbon metabolism of Chinese hamster ovary (CHO) cells, the most widely used host for industrial production of ...
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Ma, Zeqiang (2012-03-28)Department: Biomedical InformaticsTandem mass spectrometry-based shotgun proteomics has become a widespread technology for analyzing complex protein mixtures. Assessing the full information content of shotgun proteomics experiments has motivated a series ...
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Wang, Dong (2012-11-05)Department: Biomedical InformaticsIn shotgun proteomics, database search algorithms rely on fragmentation models to predict fragment ions that should be observed for a given peptide sequence. The most widely used strategy (Naïve model) is oversimplified, ...
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Straub, Peter Steven (2010-12-06)Department: Biomedical InformaticsShotgun liquid chromatography/tandem mass spectrometry (LC-MS/MS) technology provides data sets rich in the type of information required proteomic quantitation; however, these data are not fully exploited by existing tools. ...
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Kochen, Michael Allen (2015-07-06)Department: Biomedical InformaticsLipid identification from data sets produced with high-throughput technologies is essential to discovery in lipidomics experiments. A number of software tools for making lipid identifications from tandem spectra have been ...
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Ma, Zeqiang (2009-07-15)Department: Biomedical InformaticsTandem mass spectrometry-based shotgun proteomics has become a widespread technology for analyzing complex protein mixtures. A number of database searching algorithms have been developed to assign peptide sequences to ...
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Chen, Yao-Yi (2012-05-15)Department: Biomedical InformaticsSpectral counting has become a widely used approach for comparing protein abundance in label-free shotgun proteomics. However, when analyzing complex samples, the ambiguity of matching between peptides and proteins greatly ...
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Parson, Whitney Beth (2010-08-04)Department: BiochemistryMatrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) can provide the spatial distribution, relative abundance, and molecular identity of thousands of analytes directly from tissue sections. Due to the ...