Browsing by Author "David Bader"
Now showing items 1-20 of 27
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Landino, Jennifer Elaine (2017-03-30)Department: Cell and Developmental BiologyThe final steps of cell division are tightly coordinated in space and time but whether mechanisms exist to couple the actin and microtubule cytoskeletons during anaphase and cytokinesis (C phase) is largely unknown. We ...
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Smith, Travis Kirk (2007-04-11)Department: Cell and Developmental BiologyThe work contained in this document describes the generation of new immunoreagents for Bves study, and our identification of a Bves-interacting protein. After generating new monoclonal antibodies to the Bves protein, I ...
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Winters, Nichelle Irene (2012-08-06)Department: Cell and Developmental BiologyMesothelium is a simple squamous epithelium that forms the surface layer of all coelomic cavities and organs. Despite its widespread localization, mesothelial development has been studied almost exclusively in the heart. ...
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Ripley, Anna Nesset (2004-03-29)Department: Cell and Developmental BiologyI will introduce two novel genes isolated by my laboratory, hole and bves. This document will show that the benefits of gene discovery are invaluable. Bves, a novel family of cell adhesion molecules have been identified ...
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Osler, Megan Emery (2005-11-01)Department: Cell and Developmental BiologyThe work contained in this document provides the first description and characterization of Bves, a gene product identified by our laboratory, in epithelial cell types. Studies addressed a central hypothesis that Bves plays ...
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Soukoulis, Victor (2005-03-25)Department: Cell and Developmental BiologyLIS1 and NudE(L) are partner proteins in a conserved pathway regulating the function of dynein and microtubules. Members of the LIS1 pathway play a critical role in fundamental cellular processes, such as differentiation, ...
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Williams, Charles Houston III (2017-02-28)Department: Cell and Developmental BiologySmall molecules have value in their ability to modulate protein activity in ways that are not accessible using conventional genetic methods, and their potential to be developed into therapeutics. As genetic causes of human ...
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Poindexter, Shenika Vonsha (2015-04-13)Department: Cancer BiologyCANCER BIOLOGY Critical Regulators of Epithelial Homeostasis and Intestinal Crypt Regeneration: Identification of Novel BVES/BCAR3 Signaling Complex in EMT and Tumorigenesis and Biological Implications for MTG16 in Stem ...
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Wiebe, Peter O. (2007-08-02)Department: Molecular Physiology and BiophysicsThe transcription factor Pdx1 is expressed throughout the pancreas early, but selectively in insulin-producing cells postnatally. Previous studies showed that conserved regulatory regions, Areas I and II (Pdx1PB), directed ...
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Williams, Megan Ann (2015-07-20)Department: NeuroscienceThe dysfunction of dopamine signaling can contribute to mood disorders and drug abuse. Dopamine neurons do not belong to one homogenous group and differ in their electrophysiological properties and molecular expression ...
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Miller, Paul Myron (2010-08-02)Department: Cell and Developmental BiologyThis project provides a detailed characterization of the CLASP-dependent microtubule array at the Golgi in terms of function and regulation. First, I briefly outline the process of MT nucleation at the Golgi and highlight ...
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Marjoram, Lindsay Taylor (2010-12-04)Department: Cell and Developmental BiologyThe spatiotemporally dynamic distribution of instructive ligands within embryonic tissue, and their feedback antagonists, including inherent stabilities and rates of clearance, are affected by interactions with cell surfaces ...
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Petersen, Christine Pope (2016-03-30)Department: Cell and Developmental BiologySpasmolytic polypeptide-expression metaplasia (SPEM) develops in the atrophic stomach and progresses to an intestinalized SPEM in the setting of inflammation. Different immune deficient mouse models determined that T-cells, ...
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Anderson-Daniels, Jordan (2019-10-08)Department: Microbiology and ImmunologyHIV-1 is the major etiologic agent of AIDS, for which there is presently no cure or vaccine. The capsid is the structural component of HIV-1: it serves many functions during viral replication, and it is the product of ...
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Multiplex biomaterial matrix cues regulate redox status and stemness in human mesenchymal stem cells Crowder, Spencer William (2014-04-26)Department: Biomedical EngineeringHuman mesenchymal stem cells (hMSCs) offer therapeutic potential for clinical applications but exhibit a decline in overall health when isolated from aging patients or serially expanded in vitro. hMSCs have been shown to ...
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Moynihan, Katherine Lynn (2009-12-07)Department: Cell and Development BiologyThis project characterizes CENP-F protein function at a cellular and organ level. First, I outline our plan used to identify novel binding partners. The first binding partner I describe is syntaxin 4 and the interaction ...
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Chen, Tony Wayne (2014-12-19)Department: Cell and Developmental BiologyThe Notch signaling pathway is an essential cell-cell signaling pathway that is involved in cell fate decisions and cell differentiation during early metazoan development. In humans, the Notch pathway is misregulated in ...
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Liu, Jiang (2013-02-19)Department: Cell and Developmental BiologySonic hedgehog (Shh), a secreted signaling molecule, is generated from the posterior limb margin and essential in regulating anterior-posterior (A-P) patterning as well as growth and differentiation of limb mesenchyme. ...
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Andrews, Omozusi E. (2014-07-28)Department: Biological SciencesSmall noncoding RNAs including miRNAs and siRNAs play significant roles in gene regulation via the mechanism of RNA interference (RNAi) and have been exploited to conduct loss-of-function studies. The discovery that these ...
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Cross, Emily Elizabeth (2012-01-26)Department: Cell and Developmental BiologyEpicardial development is a complex process that involves tightly regulated coordination of concurrent cellular behaviors ranging from sheet migration to secretion. The regulation of these behaviors is poorly understood, ...