Browsing by Author "David A. Jacobson, Ph.D."
Now showing items 1-4 of 4
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Carrington, Sheridan Jared S (2019-03-22)Department: Molecular Physiology and BiophysicsKir7.1 is an inwardly rectifying potassium channel with important roles in the regulation of the membrane potential in retinal pigment epithelium, uterine smooth muscle, and hypothalamic neurons. Regulation of G protein–coupled ...
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Barnes, Tammy Michelle (2015-01-07)Department: Molecular Physiology and BiophysicsInappropriate glucagon secretion contributes to hyperglycemia in inflammatory disease. Previous work implicates the pro-inflammatory cytokine, interleukin-6 (IL-6), in glucagon secretion. IL-6 knock-out mice have a blunted ...
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Wang, Xiaohan (2018-02-13)Department: NeuroscienceAppropriate Ca2+ influx through the plasma membrane plays a key role in neuronal excitability and plasticity. Neuronal excitation activates voltage-gated L-type (CaV1.x) Ca2+ channels (LTCCs) that results in nuclear CREB ...
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Hutchens, Troy John (2015-08-20)Department: Chemical and Physical BiologyThe loss of inhibition of glucagon secretion exacerbates hyperglycemia in types 1 and 2 diabetes. However, the molecular mechanisms that regulate glucagon secretion in unaffected and diabetic states remain relatively ...