Browsing by Author "Claus Schneider"
Now showing items 1-7 of 7
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Jin, Jing (2013-09-19)Department: PharmacologyBiosynthesis of lipid mediators including the leukotrienes, lipoxins, eoxins, resolvins, and protectins entails the lipoxygenase (LOX) catalyzed synthesis of an allylic epoxide intermediate, designated as leukotriene A4 ...
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Mazalouskas, Matthew David (2014-04-14)Department: PharmacologyThe macromolecular assembly of protein serine/threonine phosphatase•kinase complexes mechanistically enhances the speed and fidelity of cell signaling events. These signaling modules allow for acute regulation of substrates ...
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Browne, Christopher Michael (2013-06-04)Department: BiochemistryThis dissertation focuses on the biochemical and genetic characterization of the protein-protein interaction in the budding yeast Saccharomyces cerevisiae between the cytosolic translation initiation guanine nucleotide ...
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Sprinkel, Katie Connors (2016-04-08)Department: Interdisciplinary Studies: Analytical PharmacologyEicosanoids, such as prostaglandins, leukotrienes, hydroxy- and epoxy-derivatives of arachidonic acid (AA), are lipid autacoids that regulate constitutive as well as inflammatory processes. Prostaglandins (PGs) and ...
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Sohl, Christal Dyane (2010-06-23)Department: BiochemistryThe kinetic characterization of cytochrome P450s that catalyze multi-step, sequential reactions is the focus of this work. Two novel substrates were identified for P450 1A2, one of which showed a high degree of homotropic ...
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Gordon, Odaine Narado (2014-04-19)Department: PharmacologyThe dietary polyphenol curcumin shows great promise as an anti-cancer and anti-inflammatory agent. While many cellular targets of curcumin have been identified, the chemical mechanisms whereby these targets are affected ...
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Zheng, Yuxiang (2010-12-10)Department: PharmacologyThe goal of my thesis research is to elucidate the catalytic mechanism and physiological function of the atypical mammalian lipoxygenase, epidermal lipoxygenase-3. Although named as a lipoxygenase based on sequence homology ...